ArticleNature neuroscience2016
Unstable neurons underlie a stable learned behavior.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Realignment of representational drift in mouse visual cortex via flexible electrode arrays.Nature biomedical engineering · 2026Article
- Manifold-constrained plasticity enables stable learning in recurrent neural circuits.PLoS computational biology · 2026Article
- Purinergic signaling promotes gliomagenesis through nuclear calcium transients.bioRxiv : the preprint server for biology · 2026Article
- Long-term neuron tracking reveals balance of stability and plasticity in functional properties.PloS one · 2026Article
- Article
- Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation.Cell reports · 2024Article
- Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning.iScience · 2024Article
- Article
- Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.eLife · 2024Article
- Unsupervised restoration of a complex learned behavior after large-scale neuronal perturbation.Nature neuroscience · 2024Article
- Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.Cell reports · 2024Article
- Daily singing of adult songbirds functions to maintain song performance independently of auditory feedback and age.Communications biology · 2024Article
- Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD.bioRxiv : the preprint server for biology · 2024Article
- Article
- Telemetry reveals rapid duel-driven canary song plasticity in a competitive social environment.Frontiers in psychology · 2024Article
- Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior.bioRxiv : the preprint server for biology · 2023Article
- Tauopathy severely disrupts homeostatic set-points in emergent neural dynamics but not in the activity of individual neurons.bioRxiv : the preprint server for biology · 2023Article
- Article
- MicroLED light source for optical sectioning structured illumination microscopy.Optics express · 2023Article
- A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo.Communications biology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Motor skills can be maintained for decades, but the biological basis of this memory persistence remains largely unknown. The zebra finch, for example, sings a highly stereotyped song that is stable for years, but it is not known whether the precise neural patterns underlying song are stable or shift from day to day. Here we demonstrate that the population of projection neurons coding for song in the premotor nucleus, HVC, change from day to day. The most dramatic shifts occur over intervals of sleep. In contrast to the transient participation of excitatory neurons, ensemble measurements dominated by inhibition persist unchanged even after damage to downstream motor nerves. These observations offer a principle of motor stability: spatiotemporal patterns of inhibition can maintain a stable scaffold for motor dynamics while the population of principal neurons that directly drive behavior shift from one day to the next.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.