ArticleIEEE transactions on bio-medical engineering2017
Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness.
Article in IEEE transactions on bio-medical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Translational Models for Glioblastoma: Revolutionizing Drug Development and Personalized Medicine through Clinical Insights.Theranostics · 2026Review
- Data-driven spatio-temporal modelling of glioblastoma.Royal Society open science · 2023Review
- Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution.Current opinion in systems biology · 2019Article
- Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model.Journal of theoretical biology · 2018Article
- Multiscale Tumor Modeling With Drug Pharmacokinetic and Pharmacodynamic Profile Using Stochastic Hybrid System.Cancer informatics · 2018Review
- 3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy.Cancer research · 2017Article
- Blood vessel tortuosity selects against evolution of aggressive tumor cells in confined tissue environments: A modeling approach.PLoS computational biology · 2017Article
- Editorial: Special Section on Multiscale Cancer Modeling.IEEE transactions on bio-medical engineering · 2017Article
- Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer.Molecular systems biology · 2017Article
- Automated analysis of co-localized protein expression in histologic sections of prostate cancer.PloS one · 2017Article
- Targeting the tumor microenvironment in pediatric gliomas: Advances and future directions in immunotherapy.Neuro-oncology advancesReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIn glioblastoma, the crosstalk between vascular endothelial cells (VECs) and glioma stem cells (GSCs) has been shown to enhance tumor growth. We propose a multiscale mathematical model to study this mechanism, explore tumor growth under various initial and microenvironmental conditions, and investigate the effects of blocking this crosstalk.
methodsWe develop a hybrid continuum-discrete model of highly organized vascularized tumors. VEC-GSC crosstalk is modeled via vascular endothelial growth factor (VEGF) production by tumor cells and by secretion of soluble factors by VECs that promote GSC self-renewal and proliferation.
resultsVEC-GSC crosstalk increases both tumor size and GSC fraction by enhancing GSC activity and neovascular development. VEGF promotes vessel formation, and larger VEGF sources typically increase vessel numbers, which enhances tumor growth and stabilizes the tumor shape. Increasing the initial GSC fraction has a similar effect. Partially disrupting the crosstalk by blocking VEC secretion of GSC promoters reduces tumor size but does not increase invasiveness, which is in contrast to antiangiogenic therapies, which reduce tumor size but may significantly increase tumor invasiveness. SIGNIFICANCE: Multiscale modeling supports the targeting of VEC-GSC crosstalk as a promising approach for cancer therapy.
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