Evidence map›Paper›PMID 27723473›Full record

ReviewThe Journal of nutritional biochemistry2017

Therapeutic properties of green tea against environmental insults.

Lixia Chen, Huanbiao Mo, Ling Zhao, Weimin Gao, Shu Wang, Meghan M Cromie, Chuanwen Lu, Jia-Sheng Wang, Chwan-Li Shen

Abstract readReview
In one paragraph

Review in The Journal of nutritional biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Oxidative medicine and cellular longevity · 2021
    Article
  15. Review
  16. Green Tea Polyphenols Promote Functional Recovery from Peripheral Nerve Injury in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lixia Chen1966 Services, Irving, TX, USA.
Huanbiao MoDepartment of Nutrition, Byrdine F. Lewis School of Nursing and Health Professions, Georgia State University, Atlanta, GA, USA.
Ling ZhaoDepartment of Nutrition, University of Tennessee, Knoxville, TN, USA.
Weimin GaoDepartment of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX, USA.
Shu WangDepartment of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA.
Meghan M CromieDepartment of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX, USA.
Chuanwen Lu1966 Services, Irving, TX, USA.
Jia-Sheng WangDepartment of Environmental Health Science, University of Georgia, Athens, GA, USA.
Chwan-Li ShenDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, USA. Electronic address: leslie.shen@ttuhsc.edu.
Texas Tech University · USGeorgia State University · USUniversity of Georgia · USUniversity of Tennessee at Knoxville · US

Funding

Preparation for GTP long-term clinical study on bone healthU01AT006691 · NCCIH · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI SHEN, CHWAN-LI L · 2012 to 2013
$670k
NCCIH NIH HHS U01 AT006691
6 · The paper itself

Abstract

Pesticides, smoke, mycotoxins, polychlorinated biphenyls (PCBs), and arsenic are the most common environmental toxins and toxicants to humans. These toxins and toxicants may impact on human health at the molecular (DNA, RNA, or protein), organelle (mitochondria, lysosome, or membranes), cellular (growth inhibition or cell death), tissue, organ, and systemic levels. Formation of reactive radicals, lipid peroxidation, inflammation, genotoxicity, hepatotoxicity, embryotoxicity, neurological alterations, apoptosis, and carcinogenic events are some of the mechanisms mediating the toxic effects of the environmental toxins and toxicants. Green tea, the nonoxidized and nonfermented form of tea that contains several polyphenols, including green tea catechins, exhibits protective effects against these environmental toxins and toxicants in preclinical studies and to a much-limited extent, in clinical trials. The protective effects are collectively mediated by antioxidant, antiinflammatory, antimutagenic, hepatoprotective and neuroprotective, and anticarcinogenic activities. In addition, green tea modulates signaling pathway including NF-κB and ERK pathways, preserves mitochondrial membrane potential, inhibits caspase-3 activity, down-regulates proapoptotic proteins, and induces the phase II detoxifying pathway. The bioavailability and metabolism of green tea and its protective effects against environmental insults induced by pesticides, smoke, mycotoxins, PCBs, and arsenic are reviewed in this paper. Future studies with emphasis on clinical trials should identify biomarkers of green tea intake, examine the mechanisms of action of green tea polyphenols, and investigate potential interactions of green tea with other toxicant-modulating dietary factors.

Indexed as

TeaArsenicBiological AvailabilityCatechinEnvironmental ExposureHumansMycotoxinsNeoplasmsPesticidesPolychlorinated BiphenylsArsenicCatechinMycotoxinsPesticidesPolychlorinated BiphenylsTeaCigarette smokeGreen teaHeavy metalMycotoxinPCBPesticides

Identifiers

PMID27723473
PMCPMC5124528
OpenAlexW2399473613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.