ArticleVirulence2017
Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection.
Article in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Translation control by altered start codon usage as a means of modulating the general stress response and virulence in Listeria monocytogenes.PLoS genetics · 2026Article
- Beyond antimicrobial resistance: MATE-type efflux pump FepA contributes to flagellum formation and virulence inApplied and environmental microbiology · 2025Article
- The role of proteinaceous toxins secreted byFEMS microbes · 2024Review
- Interbacterial competition mediated by the type VIIb secretion system.Microbiology (Reading, England) · 2023Review
- Article
- Evolving understanding of the type VII secretion system in Gram-positive bacteria.PLoS pathogens · 2022Article
- Article
- A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence.PLoS pathogens · 2021Article
- The Type VII Secretion System ofAnnual review of microbiology · 2021Article
- Extreme genetic diversity in the type VII secretion system ofMicrobiology (Reading, England) · 2021Article
- Substrate Interaction with the EssC Coupling Protein of the Type VIIb Secretion System.Journal of bacteriology · 2020Article
- Article
- Infect and Inject: HowMicrobiology spectrum · 2019Review
- The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.Cell · 2018Article
- MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence.Nucleic acids research · 2018Article
- Comparative genomics of human and non-human Listeria monocytogenes sequence type 121 strains.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell envelope, this facultative intracellular pathogen engages a set of specialized secretion systems. Here we show that L. monocytogenes EGDe uses a specialized secretion system, named ESX-1, to secrete EsxA, a homolog of the virulence determinants ESAT-6 and EsxA of Mycobacterium tuberculosis and Staphylococcus aureus, respectively. Our data show that the L. monocytogenes ESX-1 secretion system and its substrates are dispensable for bacterial invasion and intracellular multiplication in eukaryotic cell lines. Surprisingly, we found that the EssC-dependent secretion of EsxA has a detrimental effect on L. monocytogenes in vivo infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.