ArticleFly2017
Successive requirement of Glass and Hazy for photoreceptor specification and maintenance in Drosophila.
Article in Fly, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity.bioRxiv : the preprint server for biology · 2026Article
- A Co-Expressed Cluster of Genes in the Anterior Brain of Female Crickets Activated by a Species-Specific Calling Song.International journal of molecular sciences · 2026Article
- Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors.Seminars in cell & developmental biology · 2024Review
- The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye.Development (Cambridge, England) · 2022Article
- New regulators of Drosophila eye development identified from temporal transcriptome changes.Genetics · 2021Article
- Article
- A Genetic Model of the Connectome.Neuron · 2020Article
- Daytime colour preference in Drosophila depends on the circadian clock and TRP channels.Nature · 2019Article
- Multilevel regulation of the glass locus during Drosophila eye development.PLoS genetics · 2019Article
- Glass confers rhabdomeric photoreceptor identity inEvoDevo · 2019Article
- Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode.PLoS genetics · 2018Article
- Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye.PLoS genetics · 2018Article
- Age- and Wavelength-Dependency ofFrontiers in behavioral neuroscience · 2017Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of the insect compound eye requires a highly controlled interplay between transcription factors. However, the genetic mechanisms that link early eye field specification to photoreceptor terminal differentiation and fate maintenance remain largely unknown. Here, we decipher the function of 2 transcription factors, Glass and Hazy, which play a central role during photoreceptor development. The regulatory interactions between Glass and Hazy suggest that they function together in a coherent feed-forward loop in all types of Drosophila photoreceptors. While the glass mutant eye lacks the expression of virtually all photoreceptor genes, young hazy mutants correctly express most phototransduction genes. Interestingly, the expression of these genes is drastically reduced in old hazy mutants. This age-dependent loss of the phototransduction cascade correlates with a loss of phototaxis in old hazy mutant flies. We conclude that Glass can either directly or indirectly initiate the expression of most phototransduction proteins in a Hazy-independent manner, and that Hazy is mainly required for the maintenance of functional photoreceptors in adult flies.
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