Evidence map›Paper›PMID 27722973›Full record

ArticleClinical rheumatology2017

Primary Raynaud's phenomenon and nailfold videocapillaroscopy: age-related changes in capillary morphology.

Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Barbara Ruaro, Amelia Chiara Trombetta, Maurizio Cutolo, Sabrina Paolino

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Carmen PizzorniResearch Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy. carmen.pizzorni@unige.it.
Alberto SulliResearch Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Vanessa SmithDepartment of Rheumatology, Department of Internal Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium.
Barbara RuaroResearch Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Amelia Chiara TrombettaResearch Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Maurizio CutoloResearch Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Sabrina PaolinoResearch Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Ospedale Policlinico San Martino · ITGhent University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to detect by nailfold videocapillaroscopy (NVC) the presence of age-related capillary morphological patterns in a large cohort of subjects affected by primary Raynaud's phenomenon (PRP). NVC was performed in 877 patients affected by PRP, divided into three age groups: <35, 35-55 and >55 years. The following qualitative parameters were assessed and compared in the three groups of patients: apical dilations, irregular (non-homogeneous) dilations, venous branch dilations, microhaemorrhages, tortuosities and subpapillary venous plexus visibility. Patients with either irregular dilations or venous branch dilations were found significantly younger than those without (p < 0.0001). The presence of either irregular or venous branch dilations seems to exclude the presence of apical dilations. Patients with microhaemorrhages were found significantly younger than those without (p = 0.05), and 81 % of patients without microhaemorrhages did not show irregular and venous branch dilations. The subpapillary venous plexus seems more visible in subjects with age < 35, as well as in those with age > 55 years (p < 0.0001). A statistically significant negative correlation was found between presence of apical and irregular dilations (p < 0.0001), apical dilations and venous branch dilations (p = 0.02), apical dilations and tortuosities (p = 0.0005), microhaemorrhages and tortuosities (p < 0.0001) and venous branch dilations and tortuosities (p = 0.02). Finally, a statistically significant positive correlation was found between irregular and venous branch dilations (p < 0.0001), irregular dilations and microhaemorrhages (p < 0.0001) and venous branch dilations and microhaemorrhages (p < 0.0001). In conclusion, our study detected different age-related morphological capillary changes mainly in younger patients with PRP, as well as statistically significant correlations between the presence of different capillary variables.

Indexed as

AdultAge FactorsCapillariesFemaleHumansMaleMicroscopic AngioscopyMiddle AgedNailsRaynaud DiseaseAgingCapillary morphologyConnective tissue diseasesNailfold videocapillaroscopyPrimary Raynaud’s phenomenon

Identifiers

PMID27722973
OpenAlexW2528263071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.