Evidence map›Paper›PMID 27722798›Full record

ArticleEuropean radiology2017

Detection of single-phase CTA occult vessel occlusions in acute ischemic stroke using CT perfusion-based wavelet-transformed angiography.

Wolfgang G Kunz, Wieland H Sommer, Lukas Havla, Franziska Dorn, Felix G Meinel, Olaf Dietrich, Grete Buchholz, Birgit Ertl-Wagner, Kolja M Thierfelder

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Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wolfgang G KunzInstitute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Marchioninistr. 15, 81377, Munich, Germany.
Wieland H SommerInstitute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Marchioninistr. 15, 81377, Munich, Germany.
Lukas HavlaJosef Lissner Laboratory for Biomedical Imaging of the Institute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Munich, Germany.
Franziska DornDepartment of Neuroradiology, Ludwig-Maximilian-University Hospital Munich, Munich, Germany.
Felix G MeinelInstitute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Marchioninistr. 15, 81377, Munich, Germany.
Olaf DietrichJosef Lissner Laboratory for Biomedical Imaging of the Institute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Munich, Germany.
Grete BuchholzDepartment of Neurology, Ludwig-Maximilian-University Hospital Munich, Munich, Germany.
Birgit Ertl-WagnerInstitute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Marchioninistr. 15, 81377, Munich, Germany.
Kolja M ThierfelderInstitute for Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, Marchioninistr. 15, 81377, Munich, Germany. kolja.thierfelder@med.lmu.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the detection rate of intracranial vessel occlusions using CT perfusion-based wavelet-transformed angiography (waveletCTA) in acute ischemic stroke patients, in whom single-phase CTA (spCTA) failed to detect an occlusion.

methodsSubjects were selected from a cohort of 791 consecutive patients who underwent multiparametric CT including whole-brain CT perfusion. Inclusion criteria were (1) significant cerebral blood flow (CBF) deficit, (2) no evidence of vessel occlusion on spCTA and (3) follow-up-confirmed acute ischemic infarction. waveletCTA was independently analysed by two readers regarding presence and location of vessel occlusions. Logistic regression analysis was performed to identify predictors of waveletCTA-detected occlusions.

resultsFifty-nine patients fulfilled the inclusion criteria. Overall, an occlusion was identified using waveletCTA in 31 (52.5 %) patients with negative spCTA. Out of 47 patients with middle cerebral artery infarction, 27 occlusions (57.4 %) were detected by waveletCTA, mainly located in the M2 (15) and M3 segments (8). The presence of waveletCTA-detected occlusions was associated with larger CBF deficit volumes (odds ratio (OR) = 1.335, p = 0.010) and shorter times from symptom onset (OR = 0.306, p = 0.041).

conclusionswaveletCTA is able to detect spCTA occult vessel occlusions in about half of acute ischemic stroke patients and may potentially identify more patients eligible for endovascular therapy. KEY POINTS: • waveletCTA is able to detect spCTA occult vessel occlusions in stroke patients. • waveletCTA-detected occlusions are associated with larger cerebral blood flow deficits. • waveletCTA has the potential to identify more patients eligible for endovascular therapy. • waveletCTA implies neither additional radiation exposure nor extra contrast agent.

Indexed as

AgedBrainBrain IschemiaCerebral AngiographyCerebrovascular CirculationCohort StudiesComputed Tomography AngiographyContrast MediaFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedStrokeContrast MediaAngiographyStrokeThrombectomyThrombolysisWavelet transform

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.