Evidence map›Paper›PMID 27722792›Full record

ArticleMetabolic brain disease2017

Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia.

Meredith Meyer, Attila D Kovács, David A Pearce

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Meredith MeyerSanford Children's Health Research Center, Sanford Research, 2301 E. 60th Street, Sioux Falls, SD, 57104, USA.
Attila D KovácsSanford Children's Health Research Center, Sanford Research, 2301 E. 60th Street, Sioux Falls, SD, 57104, USA.
David A PearceSanford Children's Health Research Center, Sanford Research, 2301 E. 60th Street, Sioux Falls, SD, 57104, USA. PearceD@SanfordHealth.org.
Sanford Research · US

Funding

The Autoimmune Response of Battens DiseaseR01NS044310 · NINDS · UNIVERSITY OF ROCHESTER · PI PEARCE, DAVID A. · 2003 to 2011
$2.3M
AMPA receptor attenuation as a new therapeutic approach for Batten diseaseR21NS067147 · NINDS · SANFORD RESEARCH/USD · PI PEARCE, DAVID A. · 2009 to 2010
$452k
NINDS NIH HHS R01 NS044310NINDS NIH HHS R21 NS067147
6 · The paper itself

Abstract

Infantile CLN1 disease, also known as infantile neuronal ceroid lipofuscinosis, is a fatal childhood neurodegenerative disorder caused by mutations in the CLN1 gene. CLN1 encodes a soluble lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1), and it is still unclear why neurons are selectively vulnerable to the loss of PPT1 enzyme activity in infantile CLN1 disease. To examine the effects of PPT1 deficiency on several well-defined neuronal signaling and cell death pathways, different toxic insults were applied in cerebellar granule neuron cultures prepared from wild type (WT) and palmitoyl protein thioesterase 1-deficient (Ppt1

Indexed as

1-Methyl-4-phenylpyridiniumAnimalsCell HypoxiaCells, CulturedDisease Models, AnimalMiceMice, KnockoutMutationNeuronsThiolester Hydrolases1-Methyl-4-phenylpyridiniumpalmitoyl-protein thioesteraseThiolester HydrolasesBatten diseaseCerebellar granule neuronsCytochrome c oxidaseInfantile CLN1 diseasePalmitoyl protein thioesterase 1Ppt1 −/−

Identifiers

PMID27722792
PMCPMC5335868
OpenAlexW2529445103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.