ArticleSoft matter2016
Clustering and jamming in epithelial-mesenchymal co-cultures.
Article in Soft matter, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Liquid crystal-like self-organization of glioblastoma is associated with consistent migration for high cell densities.Scientific reports · 2026Article
- Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations.bioRxiv : the preprint server for biology · 2026Article
- Review
- Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model.NPJ systems biology and applications · 2025Article
- Gradients in cell density and shape transitions drive collective cell migration into confining environments.Soft matter · 2025Article
- Effect of non-linear strain stiffening in eDAH and unjamming.Soft matter · 2024Article
- A toolbox to analyze collective cell migration, proliferation and cellular organization simultaneously.Cell adhesion & migration · 2023Article
- Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion.NPJ systems biology and applications · 2023Article
- Jamming Transitions in Astrocytes and Glioblastoma Are Induced by Cell Density and Tension.Cells · 2022Article
- Quantitative Analysis of Collective Migration by Single-Cell Tracking Aimed at Understanding Cancer Metastasis.International journal of molecular sciences · 2022Article
- Network Analysis Identifies Phase Transitions for Tumor With Interacting Cells.Frontiers in physiology · 2022Article
- Are cell jamming and unjamming essential in tissue development?Cells & development · 2021Review
- Exploiting differential effects of actomyosin contractility to control cell sorting among breast cancer cells.Molecular biology of the cell · 2021Article
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems.Research (Washington, D.C.) · 2021Article
- Irradiation Induces Epithelial Cell Unjamming.Frontiers in cell and developmental biology · 2020Article
- Motility-limited aggregation of mammary epithelial cells into fractal-like clusters.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.ACS biomaterials science & engineering · 2019Article
- Tissue engineering the cancer microenvironment-challenges and opportunities.Biophysical reviews · 2018Review
- Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Collective behaviors emerge from coordinated cell-cell interactions during the morphogenesis of tissues and tumors. For instance, cells may display density-dependent phase transitions from a fluid-like "unjammed" phase to a solid-like "jammed" phase, while different cell types can "self-sort". Here, we comprehensively track single cell dynamics in mixtures of sheet-forming epithelial cells and dispersed mesenchymal cells. We find that proliferating epithelial cells nucleate multicellular clusters that coarsen at a critical density, arresting migration and strengthening spatial velocity correlations. The addition of mesenchymal cells can slow cluster formation and coarsening, resulting in more dispersed individual cells with weak spatial velocity correlations. These behaviors have analogies with a jamming-unjamming transition, where the control parameters are cell density and mesenchymal fraction. This complex interplay of proliferation, clustering and correlated migration may have physical implications for understanding epithelial-mesenchymal interactions in development and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.