Evidence map›Paper›PMID 27722328›Full record

ReviewChemical Society reviews2016

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.

Zijian Zhou, Jibin Song, Liming Nie, Xiaoyuan Chen

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical Society reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 465 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
465citing papers in PubMed, 2 pooled it
74.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

465 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2,039 citations in OpenAlex.

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  18. Identification and characterization of phyllochlorin sodium as a novel chlorin-derived photosensitiser.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
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405 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Zijian ZhouCenter for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China. nielm@xmu.edu.cn and Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA. shawn.chen@nih.gov.
Jibin SongLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA. shawn.chen@nih.gov.
Liming NieCenter for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China. nielm@xmu.edu.cn.
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA. shawn.chen@nih.gov.ORCID 0000-0002-9622-0870
National Institutes of Health · USXiamen University · CN

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI CONTAG, CHRISTOPHER H · 2005 to 2014
$18.2M
Intramural NIH HHS Z99 EB999999Intramural NIH HHS ZIA EB000073NCI NIH HHS P50 CA114747
6 · The paper itself

Abstract

The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, a photosensitizer (PS) and oxygen, which greatly favors the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) the limited penetration depth of light, which restricts traditional PDT to superficial tumours; (ii) oxygen reliance does not allow PDT treatment of hypoxic tumours; (iii) light can complicate the phototherapeutic outcomes because of the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects from undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of the current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities for ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatments.

Indexed as

AnimalsHumansLightNanomedicineNanotechnologyNeoplasmsOxygenPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesOxygenPhotosensitizing AgentsReactive Oxygen Species

Identifiers

PMID27722328
PMCPMC5118097
OpenAlexW2529562623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.