ArticleWorld journal of cardiology2016
Characterization of optimal resting tension in human pulmonary arteries.
Article in World journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- The impact of antiarrhythmics on human pulmonary arteries: Ex vivo characterization.Journal of clinical and translational research · 2022Article
- Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: AnWorld journal of cardiology · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
aimTo determine the optimum resting tension (ORT) for in vitro human pulmonary artery (PA) ring preparations.
methodsPulmonary arteries were dissected from disease free sections of the resected lung in the operating theatre and tissue samples were directly sent to the laboratory in Krebs-Henseleit solution (Krebs). The pulmonary arteries were then cut into 2 mm long rings. PA rings were mounted in 25 mL organ baths or 8 mL myograph chambers containing Krebs compound (37 °C, bubbled with 21% O
resultsTwenty PA rings of internal diameter between 2-4 mm were prepared from 4 patients. In human PA rings incrementing the tension during rest stance by 0.6 gf, up to 1.6 gf significantly augmented the 40 mmol/L KCl stimulated tension. Further enhancement of active tension by 0.4 gf, up to 2.0 gf mitigate the 40 mmol/L KCl stimulated reaction. Both Myograph and the organ bath demonstrated identical conclusions, supporting that the radial optimal resting tension for human PA ring was 1.61 g.
conclusionThe radial optimal resting tension in our experiment is 1.61 gf (15.78 mN) for human PA rings.
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