Evidence map›Paper›PMID 27721833›Full record

ArticleStem cells international2016

Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects.

Tianlin Liu, Xin Zhang, Yuan Luo, Yuanliang Huang, Gang Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Application of Antioxidant Compounds in Bone Defect Repair.Antioxidants (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Flavonoid-Loaded Biomaterials in Bone Defect Repair.Molecules (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Effects of icariin on osteogenic differentiation of bone marrow stromal cells in beagle canine.International journal of clinical and experimental pathology · 2017
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Tianlin LiuLaboratory of Oral Biomedical Science and Translational Medicine, Department of Oral and Maxillofacial Surgery, School of Stomatology, Tongji University, Shanghai, China; Department of Stomatology, Shanghai East Hospital Affiliated with Tongji University, Jimo Road No. 150, Shanghai 200120, China.
Xin ZhangStomatology Hospital Affiliated with Zhejiang University College of Medicine, Hangzhou, China.ORCID 0000-0002-2202-7496
Yuan LuoLaboratory of Oral Biomedical Science and Translational Medicine, Department of Oral and Maxillofacial Surgery, School of Stomatology, Tongji University, Shanghai, China; Shanghai Stomatosis Prevention and Treatment Center, Shanghai, China.
Yuanliang HuangLaboratory of Oral Biomedical Science and Translational Medicine, Department of Oral and Maxillofacial Surgery, School of Stomatology, Tongji University, Shanghai, China; Department of Stomatology, Shanghai East Hospital Affiliated with Tongji University, Jimo Road No. 150, Shanghai 200120, China.ORCID 0000-0002-2446-119X
Gang WuDepartment of Oral Implantology and Prosthetic Dentistry, Academic Center for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, Netherlands.ORCID 0000-0001-8941-2500
Tongji University · CNAcademic Center for Dentistry Amsterdam · NLStomatology Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue engineering technique is a promising strategy to repair large-volume bone defects. In this study, we developed a 3-dimensional construct by combining icariin (a small-molecule Chinese medicine), allogeneic bone marrow-derived mesenchymal stem cells (BMSCs), and a siliceous mesostructured cellular foams-poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (SMC-PHBHHx) composite scaffold. We hypothesized that the slowly released icariin could significantly promote the efficacy of SMC-PHBHHx/allogeneic BMSCs for repairing critical-size bone defects in rats. In in vitro cellular experiments, icariin at optimal concentration (10

Identifiers

PMID27721833
PMCPMC5040948
OpenAlexW2520957989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.