Evidence map›Paper›PMID 27721782›Full record

ArticleCase reports in neurology

Role of Therapeutic Plasma Exchange in Treatment of Tumefactive Multiple Sclerosis-Associated Low CD4 and CD8 Levels.

Kristen Lew, Nishith Mewada, Sahana Ramanujam, Bahareh Hassanzadeh, John E Donahue, Leema Reddy Peddareddygari, Robert Moser, Charles Kososky, Raji P Grewal

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen LewNeuroscience Institute, Saint Francis Medical Center, Trenton, N.J., USA.
Nishith MewadaNeuroscience Institute, Saint Francis Medical Center, Trenton, N.J., USA.
Sahana RamanujamNeuroscience Institute, Saint Francis Medical Center, Trenton, N.J., USA.
Bahareh HassanzadehNeuroscience Institute, Saint Francis Medical Center, Trenton, N.J., USA.
John E DonahueDivision of Neuropathology, Department of Pathology, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, R.I., USA.
Leema Reddy PeddareddygariThe Neuro-Genetics Institute, Sharon Hill, Pa., USA.
Robert MoserDepartment of Pathology, Saint Francis Medical Center, Trenton, N.J., USA.
Charles KososkyNeuroscience Institute, Saint Francis Medical Center, Trenton, N.J., USA.
Raji P GrewalNeuroscience Institute, Saint Francis Medical Center, Trenton, N.J., USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a 35-year-old healthy male who developed central nervous system inflammatory demyelinating disease consistent with tumefactive multiple sclerosis. About 2 weeks after onset of symptoms and prior to initiation of therapy, the patient had lymphopenia and low CD4 and CD8 levels. His lymphocyte count was 400 cells/µl (850-3,900 cells/µl), CD4 was 193 cells/µl (490-1,740 cells/µl) and CD8 was 103 cells/µl (180-1,170 cells/µl). He was treated with intravenous methylprednisolone followed by therapeutic plasma exchange, the levels of CD4 and CD8 normalized, and ultimately, he recovered completely.

Indexed as

Central nervous systemInflammatory demyelinating diseaseLymphopeniaPlasma exchange

Identifiers

PMID27721782
PMCPMC5043263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.