Evidence map›Paper›PMID 27721742›Full record

ArticleFrontiers in molecular neuroscience2016

"Soldier's Heart": A Genetic Basis for Elevated Cardiovascular Disease Risk Associated with Post-traumatic Stress Disorder.

Harvey B Pollard, Chittari Shivakumar, Joshua Starr, Ofer Eidelman, David M Jacobowitz, Clifton L Dalgard, Meera Srivastava, Matthew D Wilkerson, Murray B Stein, Robert J Ursano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
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  6. Article
  7. Article
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  9. Article
  10. Post-traumatic stress disorder (PTSD) as a systemic disorder: Pathways to cardiovascular disease.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. DNA methylation correlates of PTSD: Recent findings and technical challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2019
    Review
  15. Article
  16. Genome-wide analysis of insomnia disorder.Molecular psychiatry · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Harvey B PollardDepartment of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health SciencesBethesda, MD, USA; Collaborative Health Initiative Research Program, Uniformed Services University of the Health SciencesBethesda, MD, USA.
Chittari ShivakumarCollaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
Joshua StarrDepartment of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
Ofer EidelmanDepartment of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
David M JacobowitzCollaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
Clifton L DalgardDepartment of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health SciencesBethesda, MD, USA; Collaborative Health Initiative Research Program, Uniformed Services University of the Health SciencesBethesda, MD, USA.
Meera SrivastavaDepartment of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
Matthew D WilkersonCollaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
Murray B SteinDepartment of Psychiatry, University of California, San Diego San Diego, CA, USA.
Robert J UrsanoDepartment of Psychiatry Uniformed Services University School of Medicine, Uniformed Services University of the Health SciencesBethesda, MD, USA; Center for the Study of Traumatic stress, Uniformed Services University of the Health SciencesBethesda, MD, USA.
Uniformed Services University of the Health Sciences · USUniversity of California, San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

"Soldier's Heart," is an American Civil War term linking post-traumatic stress disorder (PTSD) with increased propensity for cardiovascular disease (CVD). We have hypothesized that there might be a quantifiable genetic basis for this linkage. To test this hypothesis we identified a comprehensive set of candidate risk genes for PTSD, and tested whether any were also independent risk genes for CVD. A functional analysis algorithm was used to identify associated signaling networks. We identified 106 PTSD studies that report one or more polymorphic variants in 87 candidate genes in 83,463 subjects and controls. The top upstream drivers for these PTSD risk genes are predicted to be the glucocorticoid receptor (NR3C1) and Tumor Necrosis Factor alpha (TNFA). We find that 37 of the PTSD candidate risk genes are also candidate independent risk genes for CVD. The association between PTSD and CVD is significant by Fisher's Exact Test (

Indexed as

candidate genecardiovascular diseasepost traumatic stress disorderType 2 diabetes mellitus

Identifiers

PMID27721742
PMCPMC5033971
OpenAlexW2522492694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.