Evidence map›Paper›PMID 27721569›Full record

ArticleSensors and actuators. B, Chemical2016

Impedimetric Immunosensing in a Porous Volumetric Microfluidic Detector.

Michael S Wiederoder, Isaac Misri, Don L DeVoe

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael S WiederoderFischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA.
Isaac MisriDepartment of Mechanical Engineering, University of Maryland, College Park, Maryland, USA.
Don L DeVoeFischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA; Department of Mechanical Engineering, University of Maryland, College Park, Maryland, USA.
University of Maryland, College Park · US

Funding

Integrated polymer microfluidic device for multiplex diagnosis of viral infectionR01AI096215 · NIAID · GENEVA FOUNDATION · PI ULRICH, ROBERT G. · 2011 to 2015
$4.4M
NIAID NIH HHS R01 AI096215United States NIAID
6 · The paper itself

Abstract

A sensitive and rapid impedemetric immunosensor is demonstrated utilizing porous volumetric microfluidic detection elements and silver enhanced gold nanoparticle probes. The porous detection elements significantly increase capture probe density and decrease diffusion length scales compared to conventional planar sensors to improve target capture efficiency and enhance impedance signal. In this work, a packed bed of silica beads functionalized with antibody probes serves as a porous sensor element within a thermoplastic microchannel, with an interdigitated gold electrode microarray used to measure impedance changes caused by the concentration dependent formation of silver aggregates. The measured impedance change is independent of electrode spacing, enabling a device with low resolution electrodes to achieve a sandwich immunoassay detection limit between 1-10 ng/mL with a 4-log dynamic range, with a total assay time of 75 min.

Indexed as

conductometricimmunoassayimpedance sensingnanoparticlessilver enhancement

Identifiers

PMID27721569
PMCPMC5053616
OpenAlexW2345507320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.