Evidence map›Paper›PMID 27721567›Full record

ArticleInternational journal of computer vision2015

Stacked Predictive Sparse Decomposition for Classification of Histology Sections.

Hang Chang, Yin Zhou, Alexander Borowsky, Kenneth Barner, Paul Spellman, Bahram Parvin

Abstract read
In one paragraph

Article in International journal of computer vision, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 63 citations in OpenAlex.

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  13. Integrative Analysis of Cellular Morphometric Context Reveals Clinically Relevant Signatures in Lower Grade Glioma.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2016
    Article
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  16. NUCLEI SEGMENTATION VIA SPARSITY CONSTRAINED CONVOLUTIONAL REGRESSION.Proceedings. IEEE International Symposium on Biomedical Imaging · 2015
    Article
  17. Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Hang ChangLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yin ZhouLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Alexander BorowskyCenter for Comparative Medicine, UC Davis, Davis, CA, USA.
Kenneth BarnerECE Department, University of Delaware, Newark, DE, USA.
Paul SpellmanCenter for Spatial Systems Biomedicine, Oregon Health Sciences University, Portland, ON, USA.
Bahram ParvinLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Lawrence Berkeley National Laboratory · USOregon Health & Science University · USUniversity of California, Davis · USUniversity of Delaware · USUniversity of Nevada, Reno · US

Funding

TCGA Data Analysis Center at BerkeleyU24CA143799 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SPEED, TERENCE PAUL, SPELLMAN, PAUL T. · 2009 to 2016
$4.9M
High Content Representation and Association of 3D Cell Culture ModelsR01CA140663 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PARVIN, BAHRAM A. · 2011 to 2014
$2.4M
NCI NIH HHS R01 CA140663NCI NIH HHS U24 CA143799United States NCI
6 · The paper itself

Abstract

Image-based classification of histology sections, in terms of distinct components (e.g., tumor, stroma, normal), provides a series of indices for histology composition (e.g., the percentage of each distinct components in histology sections), and enables the study of nuclear properties within each component. Furthermore, the study of these indices, constructed from each whole slide image in a large cohort, has the potential to provide predictive models of clinical outcome. For example, correlations can be established between the constructed indices and the patients' survival information at cohort level, which is a fundamental step towards personalized medicine. However, performance of the existing techniques is hindered as a result of large technical variations (e.g., variations of color/textures in tissue images due to non-standard experimental protocols) and biological heterogeneities (e.g., cell type, cell state) that are always present in a large cohort. We propose a system that automatically learns a series of dictionary elements for representing the underlying spatial distribution using stacked predictive sparse decomposition. The learned representation is then fed into the spatial pyramid matching framework with a linear support vector machine classifier. The system has been evaluated for classification of distinct histological components for two cohorts of tumor types. Throughput has been increased by using of graphical processing unit (GPU), and evaluation indicates a superior performance results, compared with previous research.

Indexed as

ClassificationSparse codingTissue histologyUnsupervised feature learning

Identifiers

PMID27721567
PMCPMC5051579
OpenAlexW2001810343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.