Evidence map›Paper›PMID 27721548›Full record

Observational studyIndian journal of pharmacology

Prescribing patterns of medicines in chronic kidney disease patients on maintenance hemodialysis.

Sourav Chakraborty, Saugata Ghosh, Avishek Banerjea, Radha Raman De, Avijit Hazra, Swapan Kumar Mandal

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Mediation effect of self-neglect in family resilience and medication adherence in older patients undergoing maintenance hemodialysis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  7. Article
  8. Article
  9. Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece.International journal of environmental research and public health · 2020
    Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sourav ChakrabortyDepartment of Pharmacology, R.G.Kar Medical College, Kolkata, West Bengal, India.
Saugata GhoshDepartment of Pharmacology, R.G.Kar Medical College, Kolkata, West Bengal, India.
Avishek BanerjeaDepartment of Pharmacology, R.G.Kar Medical College, Kolkata, West Bengal, India.
Radha Raman DeDepartment of Pharmacology, R.G.Kar Medical College, Kolkata, West Bengal, India.
Avijit HazraDepartment of Pharmacology, IPGMER, Kolkata, West Bengal, India.
Swapan Kumar MandalDepartment of Hemodialysis, R.G.Kar Medical College, Kolkata, West Bengal, India.
R. G. Kar Medical College and Hospital · INInstitute of Post Graduate Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study medicine prescribing pattern for chronic kidney disease (CKD) patients on maintenance hemodialysis. MATERIALS AND

methodsThis prospective observational study was conducted in hemodialysis unit of a teaching hospital with adult CKD patients on maintenance hemodialysis. Patients' clinical profile, drug-use pattern, and medication-related problem data were captured in a structured case report form and the data were analyzed descriptively. Adherence level was assessed by Morisky Medication-Taking Adherence Scale 4-item.

resultsData from 100 patients recruited over 6 months have been analyzed. The median (interquartile range [IQR]) age was 51 (42-57) years; 57% were male, mean [standard deviation (SD)] urea level was 160.11 (70.32) mg/dL, mean (SD) creatinine level was 8.73 (5.29) mg/dL. A large number (46%) were suffering from diabetic nephropathy. The common comorbidities were anemia (89%) followed by hypertension (85%). The median (IQR) number of drugs per prescription was 10 (9-13), with the bulk being cardiovascular drugs (23.41%) followed by gastrointestinal drugs (15.76%) and vitamins (12.29%). The median (IQR) number of potential drug-drug interaction per prescription was 2 (2-3). The incidence of adverse drug reactions (ADRs) was 46% with hyponatremia being most common (32%), followed by hypoglycemia (16%) and hypokalemia (10%). Adherence level was low in the majority (64%) of patients.

conclusionsThere is a high incidence of polypharmacy along with significant medication-related problems such as high drug-drug interactions/prescription, high incidence of ADRs, and low adherence.

Indexed as

AdultDrug InteractionsDrug-Related Side Effects and Adverse ReactionsFemaleHospitals, TeachingHumansIncidenceMaleMedication AdherenceMiddle AgedPolypharmacyPractice Patterns, Physicians'Renal DialysisRenal Insufficiency, ChronicChronic kidney diseasediabetic nephropathyhemodialysismedication adherenceprescribing patterns

Identifiers

PMID27721548
PMCPMC5051256
OpenAlexW2523754658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.