ArticleIndian journal of pharmacology
A simple colorimetric method for estimation of tramadol hydrochloride in pure and tablet dosage forms.
Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed, 18 citations in OpenAlex.
- Interpol review of controlled substances 2016-2019.Forensic science international. Synergy · 2020Review
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2 authors at 2 institutions in 1 country.
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Abstract
objectiveThe objective of this study was to develop and validate a simple method for estimation of tramadol hydrochloride (TH) in pure and pharmaceutical dosage forms using a colorimeter. MATERIALS AND
methodsTH on reaction with Eriochrome Black T in the presence of acetate buffer at pH 3.5 forms a colored complex. This complex was extracted with a fixed volume of chloroform. The optical density of this colored complex was measured against reagent blank using a colorimeter at 520 nm.
resultsBeer's law was obeyed with a good correlation coefficient (0.999) in the concentration range of 2.5 μg/ml to 10 μg/ml. Drug content estimation and recovery studies carried out on commercial tablet dosage forms demonstrated the accuracy of the method and that excipients do not cause interference. Precision and robustness were measured and found to be acceptable (% relative standard deviation <2%).
conclusionThe proposed method can be used for the rapid determination of TH content in tablets at a health-care provider level using already available staff and equipment.
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