ArticleNature communications2016
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.
7 registry-linked trialsOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 429 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
429citing papers in PubMed, 3 pooled it
50.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Three-Day Dosing NAD + Study
NCT04614714 phase2 / phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation
Nicotinamide Riboside and Milk Production in the NICU
Nicotinamide Riboside in Ulcerative Colitis
Validation of an Enzymatic Assay for Quantification of Nicotinamide Adenine Dinucleotide in Blood Plasma After Ingestion of the Vitamin B3 Variant Nicotinamide Riboside: a Randomized Controlled Trial
A Randomised Double-Masked Placebo-Controlled Trial of Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment
Comparisons of Nicotinamide Adenine Dinucleotide (NAD) Precursors for Neuroenhancement in Glaucoma Patients
NCT07693543 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation
Pilot Randomized Crossover Trial of Nicotinamide Riboside in Chronic Kidney Disease (NR-CKD Trial)
Who cites it
429 citing papers in PubMed, 3 syntheses or guidelines pooled it, 679 citations in OpenAlex.
- The adverse effects of oral niacin/nicotinamide - an overview of reviews.Eye (London, England) · 2025Pooled it
- A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.Nature medicine · 2024Pooled it
- Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues.Scientific reports · 2023Pooled it
- A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- The differential impact of three different NADNature metabolism · 2026Trial
- Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial.Frontiers in aging · 2026Trial
- Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial.GeroScience · 2025Trial
- Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.Aging cell · 2025Trial
- Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.Nature aging · 2024Trial
- Trial
- Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial.Nature communications · 2024Trial
- A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment.GeroScience · 2024Trial
- NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease.Nature communications · 2023Trial
- Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Scientific reports · 2022Trial
- Trial
- NAD+ Attenuates Neuroinflammation in Ischemic Stroke by Suppressing the cGAS- STING Pathway via Mitochondrial Homeostasis Restoration.Molecular neurobiology · 2026Article
- Article
- Miscompartmentalization of microbiota-derived TMAO is a reversible driver in autism spectrum disorder.iScience · 2026Article
- O-methylation of phenolic natural products: translational insights from resveratrol.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
369 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Samuel A J TrammellDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Mark S SchmidtDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Benjamin J WeidemannDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Philip RedpathJohn King Laboratory, School of Pharmacy, Queens University Belfast, Belfast BT7 1NN, UK.
Frank JakschChromaDex, Inc., 10005 Muirlands Blvd, Suite G, Irvine, California 92618, USA.
Ryan W DellingerChromaDex, Inc., 10005 Muirlands Blvd, Suite G, Irvine, California 92618, USA.
Zhonggang LiDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
E Dale AbelDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Marie E MigaudDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Charles BrennerDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.ORCID 0000-0002-4955-3226
University of Iowa · USChromaDex (United States) · USQueen's University Belfast · GB
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1MInsulin Resistance and Myocardial AutophagyR01HL108379 · NHLBI · UNIVERSITY OF UTAH · PI ABEL, E DALE · 2011 to 2014
$1.5MRole of Mitochondrial Protein Acetylation in the Liver Pathology of AlcoholR21AA022371 · NIAAA · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M · 2014 to 2015
$372kNHLBI NIH HHS R01 HL108379NIAAA NIH HHS R21 AA022371NIGMS NIH HHS T32 GM008629
Abstract
Nicotinamide riboside (NR) is in wide use as an NAD
Indexed as
Administration, OralAnimalsBiological AvailabilityBiomarkersHumansLeukocytes, MononuclearLiverMaleMetabolomeMice, Inbred C57BLMiddle AgedNADNiacinamidePyridinium CompoundsVitaminsBiomarkersNADNiacinamidenicotinamide-beta-ribosidenicotinic acid adenine dinucleotidePyridinium CompoundsVitamins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT03707652ClinicalTrials.gov
NCT04614714ClinicalTrials.gov
NCT05561738ClinicalTrials.gov
NCT06005350ClinicalTrials.gov
NCT06587945ClinicalTrials.gov
NCT06991712ClinicalTrials.gov
and 1 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.