ArticleScientific reports2016
Infrared vibrational spectroscopy: a rapid and novel diagnostic and monitoring tool for cystinuria.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- Renal Cell Carcinoma Discrimination through Attenuated Total Reflection Fourier Transform Infrared Spectroscopy of Dried Human Urine and Machine Learning Techniques.International journal of molecular sciences · 2024Article
- Using urine FTIR spectra to screen autism spectrum disorder.Scientific reports · 2023Article
- Spectral narrowing and broadening of Cr:ZnS/Se laser oscillation due to mode competition and spatial hole burning in the gain element.Optics express · 2023Article
- An Electromechanical Lab-on-a-Chip Platform for Colorimetric Detection of Serum Creatinine.ACS omega · 2022Article
- Prediction of Neonatal Respiratory Distress Biomarker Concentration by Application of Machine Learning to Mid-Infrared Spectra.Sensors (Basel, Switzerland) · 2022Article
- Distinguishing active from quiescent disease in ANCA-associated vasculitis using attenuated total reflection Fourier-transform infrared spectroscopy.Scientific reports · 2021Article
- Urine and stone analysis for the investigation of the renal stone former: a consensus conference.Urolithiasis · 2021Article
- Analysis of stones formed in the human gall bladder and kidney using advanced spectroscopic techniques.Biophysical reviews · 2020Review
- A New Artificial Urine Protocol to Better Imitate Human Urine.Scientific reports · 2019Article
- Label-free molecular imaging of the kidney.Kidney international · 2017Review
- Label Free Detection of Sensitive Mid-Infrared Biomarkers of Glomerulonephritis in Urine Using Fourier Transform Infrared Spectroscopy.Scientific reports · 2017Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Cystinuria is the commonest inherited cause of nephrolithiasis (~1% in adults; ~6% in children) and is the result of impaired cystine reabsorption in the renal proximal tubule. Cystine is poorly soluble in urine with a solubility of ~1 mM and can readily form microcrystals that lead to cystine stone formation, especially at low urine pH. Diagnosis of cystinuria is made typically by ion-exchange chromatography (IEC) detection and quantitation, which is slow, laboursome and costly. More rapid and frequent monitoring of urinary cystine concentration would significantly improve the diagnosis and clinical management of cystinuria. We used attenuated total reflection - Fourier transform infrared spectroscopy (ATR-FTIR) to detect and quantitate insoluble cystine in 22 cystinuric and 5 healthy control urine samples. Creatinine concentration was also determined by ATR-FTIR to adjust for urinary concentration/dilution. Urine was centrifuged, the insoluble fraction re-suspended in 5 μL water and dried on the ATR prism. Cystine was quantitated using its 1296 cm
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