Evidence map›Paper›PMID 27721421›Full record

ArticleNature communications2016

Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.

Xingbin Hu, Mayra Garcia, Lihong Weng, Xiaoman Jung, Jodi L Murakami, Bijender Kumar, Charles D Warden, Ivan Todorov, Ching-Cheng Chen

Abstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Niches in cancer: from primary tumors to metastatic disease.Journal of hematology & oncology · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The benefits of adipocyte metabolism in bone health and regeneration.Frontiers in cell and developmental biology · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xingbin HuDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Mayra GarciaDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Lihong WengDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Xiaoman JungDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Jodi L MurakamiDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Bijender KumarDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Charles D WardenBioinformatics Core, Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Ivan TodorovDepartment of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Ching-Cheng ChenDivison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Paired lg-Like Receptor as a Regulator of Hematopoietic Stem Cell FunctionR00HL087936 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, CHING-CHENG · 2010 to 2012
$747k
NCI NIH HHS P30 CA033572NHLBI NIH HHS R00 HL087936
6 · The paper itself

Abstract

Microenvironment cues received by haematopoietic stem cells (HSC) are important in regulating the choice between self-renewal and differentiation. On the basis of the differential expression of cell-surface markers, here we identify a mesenchymal stromal progenitor hierarchy, where CD45

Indexed as

HematopoiesisStem Cell NicheAnimalsAntigens, CDBone and BonesBone Marrow CellsGene Expression ProfilingGene Expression RegulationGreen Fluorescent ProteinsInjections, IntravenousMesenchymal Stem CellsMice, Inbred C57BLPhenotypeStem Cell FactorStromal CellsAntigens, CDGreen Fluorescent ProteinsStem Cell Factor

Identifiers

PMID27721421
PMCPMC5062560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.