ReviewChest2017
Pediatric OSA Syndrome Morbidity Biomarkers: The Hunt Is Finally On!
Review in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Associations of Preoperative HMGB-1 and Systemic Immune-Inflammation Index with Short-Term Behavioral Improvement After Adenotonsillectomy in Children with OSAHS.Journal of inflammation research · 2026Trial
- Nighttime sleep duration and variability in children with obstructive sleep apnea syndrome: Sociodemographic disparities and neurobehavioral outcomes.Sleep medicine · 2023Trial
- Effectiveness of Adenotonsillectomy vs Watchful Waiting in Young Children With Mild to Moderate Obstructive Sleep Apnea: A Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2020Trial
- Peripheral Mononuclear Cells Metabolomics in Obstructive Sleep Apnea Syndrome (OSAS): An Exploratory Pilot Study of Immunometabolic Signatures.International journal of molecular sciences · 2026Article
- Characteristics and clinical value of intestinal metabolites in 4 to 6-year-old children with OSAHS.BMC pediatrics · 2025Article
- Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury.Applied microbiology and biotechnology · 2024Article
- Recent progresses in gut microbiome mediates obstructive sleep apnea-induced cardiovascular diseases.FASEB bioAdvances · 2024Review
- A narrative review on obstructive sleep apnoea syndrome in paediatric population.Frontiers in neurology · 2024Review
- Sleep-Disordered Breathing among Saudi Primary School Children: Incidence and Risk Factors.Healthcare (Basel, Switzerland) · 2023Article
- Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea.Medicina (Kaunas, Lithuania) · 2023Article
- Demonstration of Accuracy and Feasibility of Remotely Delivered Oximetry: A Blinded, Controlled, Real-World Study of Regional/Rural Children with Obstructive Sleep Apnoea.Healthcare (Basel, Switzerland) · 2023Article
- Evaluation and diagnosis of pediatric obstructive sleep apnea-An update.Frontiers in sleep · 2023Review
- Pediatric polysomnography-flagging etiologies and impact on the clinical timeline.Frontiers in sleep · 2023Article
- Neurocognitive Consequences in Children with Sleep Disordered Breathing: Who Is at Risk?Children (Basel, Switzerland) · 2022Review
- Cardiometabolic risk profile in non-obese children with obstructive sleep apnea syndrome.European journal of pediatrics · 2022Article
- You Cannot Hit Snooze on OSA: Sequelae of Pediatric Obstructive Sleep Apnea.Children (Basel, Switzerland) · 2022Review
- Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea.Children (Basel, Switzerland) · 2021Review
- Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea.Pediatric investigation · 2021Review
- Validity and Cost-Effectiveness of Pediatric Home Respiratory Polygraphy for the Diagnosis of Obstructive Sleep Apnea in Children: Rationale, Study Design, and Methodology.Methods and protocols · 2021Article
- Metabolomics Analysis on Obesity-Related Obstructive Sleep Apnea After Weight Loss Management: A Preliminary Study.Frontiers in endocrinology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Since initial reports 40 years ago on pediatric OSA syndrome (OSAS) as a distinct and prevalent clinical entity, substantial advances have occurred in the delineation of diagnostic and treatment approaches. However, despite emerging and compelling evidence that OSAS increases the risk for cognitive, cardiovascular, and metabolic end-organ morbidities, routine assessment of such morbidities is seldom conducted in clinical practice. One of the major reasons for such discrepancies resides in the relatively labor-intensive and onerous steps that would be required to detect the presence of any of such morbidities, further adding to the already elevated cost of diagnosing the disorder. To circumvent these obstacles, the search for biomarker signatures of pediatric OSA and its cognitive and cardiometabolic consequences was launched, and considerable progress has occurred since then. Here, we review the current evidence for the presence of morbidity-related biomarkers among children with OSAS, and explore future opportunities in this promising arena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.