Evidence map›Paper›PMID 27720860›Full record

ArticleExperimental eye research2016

The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography.

Brent A Bell, Alex Yuan, Rose M Dicicco, Joseph Fogerty, Emma M Lessieur, Brian D Perkins

Abstract read
In one paragraph

Article in Experimental eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brent A BellOphthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States. Electronic address: bellb3@ccf.org.
Alex YuanOphthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States.
Rose M DiciccoOphthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States.
Joseph FogertyOphthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States.
Emma M LessieurOphthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States; Molecular Medicine PhD Program Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States.
Brian D PerkinsOphthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States.
Cleveland Clinic · US

Funding

Cilia Assembly and Transport in the Vertebrate RetinaR01EY017037 · NEI · TEXAS A&M UNIVERSITY · PI PERKINS, BRIAN D · 2006 to 2021
$5.5M
A Comparison of the Retinal Microglial Cell Response to Injury in Mice and ZebrafK08EY023608 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI YUAN, ALEX · 2013 to 2017
$1.0M
NEI NIH HHS K08 EY023608NEI NIH HHS R01 EY017037
6 · The paper itself

Abstract

Non-invasive imaging is an invaluable diagnostic tool in ophthalmology. Two imaging devices, the scanning laser ophthalmoscope (SLO) and spectral domain optical coherence tomography (SDOCT), emerged from the clinical realm to provide research scientists with a real-time view of ocular morphology in living animals. We utilized these two independent imaging modalities in a complementary manner to perform in vivo optical sectioning of the adult zebrafish retina. Due to the very high optical power of the zebrafish lens, the confocal depth of field is narrow, allowing for detailed en face views of specific retinal layers, including the cone mosaic. Moreover, we demonstrate that both native reflectance, as well as fluorescent features observed by SLO, can be combined with axial in-depth information obtained by SDOCT. These imaging approaches can be used to screen for ocular phenotypes and monitor retinal pathology in a non-invasive manner.

Indexed as

AnimalsDisease Models, AnimalFluorescein AngiographyFundus OculiOphthalmoscopyReproducibility of ResultsRetinal DiseasesRetinal Ganglion CellsTomography, Optical CoherenceZebrafishIn vivoMorphologyOptical sectioningRetinaSDOCTSLOZebrafish

Identifiers

PMID27720860
PMCPMC5120996
OpenAlexW2529881968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.