Evidence map›Paper›PMID 27720794›Full record

Trial reportJournal of pain and symptom management2017

Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters.

Richard R Reich, Cecile A Lengacher, Carissa B Alinat, Kevin E Kip, Carly Paterson, Sophia Ramesar, Heather S Han, Roohi Ismail-Khan, Versie Johnson-Mallard, Manolete Moscoso and 5 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain and symptom management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 26 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01177124 nacompletednot on this map

Mindfulness-Based Stress Reduction (MBSR) Symptom Cluster Trial for Breast Cancer Survivors

TypeinterventionalSponsorCecile LengacherRan2009 to 2013Enrolled300ConditionsBreast CancerArmsMBSR 6 Weeks Program
NCT04019301 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Caring for Caregivers With Mind-body Exercise

TypeinterventionalSponsorUniversity of HoustonRan2019 to 2022Enrolled47ConditionsCaregiver Distress, Physical Function, Quality of LifeArmsBaduanjin Qigong, Community-based, Baduanjin Qigong, Internet-based
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 26 syntheses or guidelines pooled it, 195 citations in OpenAlex.

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  2. Effects of yoga on depressive symptoms in breast cancer patients: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  16. A systematic review of coping skill interventions to reduce anxiety and depressive symptoms among adults with hematologic malignancies.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2022
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Richard R ReichMoffitt Cancer Center and Research Institute, Tampa, Florida, USA. Electronic address: rreich@sar.usf.edu.
Cecile A LengacherCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Carissa B AlinatCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Kevin E KipCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Carly PatersonCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Sophia RamesarCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Heather S HanMoffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Roohi Ismail-KhanMoffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Versie Johnson-MallardCollege of Nursing, University of Florida, Gainesville, Florida, USA.
Manolete MoscosoCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Pinky Budhrani-ShaniNelda C. Stark College of Nursing, Texas Woman's University, Houston, Texas, USA.
Steve ShiversUniversity of South Florida Breast Health Clinical and Research Integrated Strategic Program, Tampa, Florida, USA.
Charles E CoxDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
Matthew GoodmanDepartment of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA.
Jong ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
University of South Florida · USMoffitt Cancer Center · USTexas Woman's University · USUniversity of Florida · USUniversity of Virginia · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
MBSR Symptom Cluster Trial for Breast Cancer SurvivorsR01CA131080 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2009 to 2013
$2.7M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA131080
6 · The paper itself

Abstract

contextBreast cancer survivors (BCS) face adverse physical and psychological symptoms, often co-occurring. Biologic and psychological factors may link symptoms within clusters, distinguishable by prevalence and/or severity. Few studies have examined the effects of behavioral interventions or treatment of symptom clusters.

objectivesThe aim of this study was to identify symptom clusters among post-treatment BCS and determine symptom cluster improvement following the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) program.

methodsThree hundred twenty-two Stage 0-III post-treatment BCS were randomly assigned to either a six-week MBSR(BC) program or usual care. Psychological (depression, anxiety, stress, and fear of recurrence), physical (fatigue, pain, sleep, and drowsiness), and cognitive symptoms and quality of life were assessed at baseline, six, and 12 weeks, along with demographic and clinical history data at baseline. A three-step analytic process included the error-accounting models of factor analysis and structural equation modeling.

resultsFour symptom clusters emerged at baseline: pain, psychological, fatigue, and cognitive. From baseline to six weeks, the model demonstrated evidence of MBSR(BC) effectiveness in both the psychological (anxiety, depression, perceived stress and QOL, emotional well-being) (P = 0.007) and fatigue (fatigue, sleep, and drowsiness) (P < 0.001) clusters. Results between six and 12 weeks showed sustained effects, but further improvement was not observed.

conclusionOur results provide clinical effectiveness evidence that MBSR(BC) works to improve symptom clusters, particularly for psychological and fatigue symptom clusters, with the greatest improvement occurring during the six-week program with sustained effects for several weeks after MBSR(BC) training.

trial registrationName and URL of Registry: ClinicalTrials.gov. Registration number: NCT01177124.

Indexed as

Breast NeoplasmsCognitionFatigueFemaleHumansMiddle AgedMindfulnessQuality of LifeStress, PsychologicalSurvivorsTreatment OutcomeBreast cancerMindfulness-Based Stress Reduction (MBSR)physical symptomspost-treatmentpsychological symptomssymptom cluster

Identifiers

PMID27720794
PMCPMC7771358
OpenAlexW2528652354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.