Evidence map›Paper›PMID 27720662›Full record

ArticleJournal of the American Medical Directors Association2017

Inappropriate Fentanyl Prescribing Among Nursing Home Residents in the United States.

Kevin M Fain, Carlos Castillo-Salgado, David D Dore, Jodi B Segal, Andrew R Zullo, G Caleb Alexander

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Medical Directors Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Opioid Prescribing in the Elderly: A Systematic Review.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2020
    Review
  4. Pain Assessment, Management, and Impact Among Older Adults in Assisted Living.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2019
    Review
  5. Long-acting opioid initiation in US nursing homes.Pharmacoepidemiology and drug safety · 2019
    Article
  6. Article
  7. Prevalence of Long-Term Opioid Use in Long-Stay Nursing Home Residents.Journal of the American Geriatrics Society · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kevin M FainDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address: kfain1@jhu.edu.
Carlos Castillo-SalgadoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
David D DoreOptum Epidemiology, Waltham, MA; Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI.
Jodi B SegalCenter for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD.
Andrew R ZulloDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI.
G Caleb AlexanderDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD.
Johns Hopkins University · USBrown University · USJohns Hopkins Medicine · US

Funding

Televised Direct to Consumer Pharmaceutical Advertising and Patient OutcomesR01HL107345 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALEXANDER, G. CALEB, EMERY, SHERRY L · 2011 to 2014
$3.0M
AHRQ HHS R01 HS018960NHLBI NIH HHS R01 HL107345
6 · The paper itself

Abstract

objectiveWe quantified transdermal fentanyl prescribing in elderly nursing home residents without prior opioid use or persistent pain, and the association of individual and facility traits with opioid-naïve prescribing.

designCross-sectional study.

settingLinked Minimum Data Set (MDS) assessments; Online Survey, Certification and Reporting (OSCAR) records; and Medicare Part D claims.

participantsFrom a cross-section of all long-stay US nursing home residents in 2008 with an MDS assessment and Medicare Part D enrollment, we identified individuals (≥65 years old) who initiated transdermal fentanyl, excluding those with Alzheimer disease, severe cognitive impairment, cancer, or receipt of hospice care. MEASUREMENTS: We used Medicare Part D to select beneficiaries initiating transdermal fentanyl in 2008 and determined whether they were "opioid-naïve," defined as no opioid dispensing during the previous 60 days. We obtained resident and facility characteristics from MDS and OSCAR records and defined persistent pain as moderate-to-severe, daily pain on consecutive MDS assessments at least 90 days apart. We estimated associations of patient and facility attributes and opioid-naïve fentanyl initiation using multilevel mixed effects logistic regression modeling.

resultsAmong 17,052 residents initiating transdermal fentanyl, 6190 (36.3%) were opioid-naïve and 15,659 (91.8%) did not have persistent pain. In the regression analysis with adjustments, residents who were older (ages ≥95 odds ratio [OR] 1.69, 95% confidence interval [CI] 1.46-1.95) or more cognitively impaired (moderate-to-severe cognitive impairment, OR 1.99, 95% CI 1.73-2.29) were more likely to initiate transdermal fentanyl without prior opioid use.

conclusionMost nursing home residents initiating transdermal fentanyl did not have persistent pain and many were opioid-naïve. Changes in prescribing practices may be necessary to ensure Food and Drug Administration warnings are followed, particularly for vulnerable subgroups, such as the cognitively impaired.

Indexed as

Inappropriate PrescribingAgedAged, 80 and overAnalgesics, OpioidCross-Sectional StudiesFemaleFentanylHumansMaleNursing HomesUnited StatesUnited States Food and Drug AdministrationAnalgesics, OpioidFentanylfentanylFood and Drug AdministrationNursing homesprescription opioids

Identifiers

PMID27720662
PMCPMC9012076
OpenAlexW2528767941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.