ArticleCurrent biology : CB2016
A Surveillance System Ensures Crossover Formation in C. elegans.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 73 citations in OpenAlex.
- High-resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and structures.PLoS genetics · 2026Article
- Prophase roles of replication protein A in crossover formation and meiotic progression.Journal of microbiology (Seoul, Korea) · 2026Article
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- High-resolution global recombination mapping inbioRxiv : the preprint server for biology · 2026Article
- Expanding thebioRxiv : the preprint server for biology · 2026Article
- Article
- Bloom helicase contributes to successful crossover formation with both catalytic and structural roles in Caenorhabditis elegans meiosis.Nucleic acids research · 2025Article
- Loss of meiotic double strand breaks triggers recruitment of recombination-independent pro-crossover factors in C. elegans spermatogenesis.PLoS genetics · 2025Article
- Identification of the Polo-like kinase substrate required for homologous synapsis.The Journal of cell biology · 2025Article
- Article
- Dynamic molecular architecture of the synaptonemal complex.Science advances · 2025Article
- The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation inbioRxiv : the preprint server for biology · 2024Article
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice.Current biology : CB · 2022Article
- Article
- PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis.Molecular biology of the cell · 2022Article
- DNA repair, recombination, and damage signaling.Genetics · 2022Review
- Heterologous synapsis in C. elegans is regulated by meiotic double-strand breaks and crossovers.Chromosoma · 2021Article
- Targeting Polo-like kinase in space and time during C. elegans meiosis.Cell cycle (Georgetown, Tex.) · 2021Review
- Let's get physical - mechanisms of crossover interference.Journal of cell science · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Crossover (CO) recombination creates a physical connection between homologs that promotes their proper segregation at meiosis I (MI). Failure to realize an obligate CO causes homologs to attach independently to the MI spindle and separate randomly, leading to nondisjunction. However, mechanisms that determine whether homolog pairs have received crossovers remain mysterious. Here we describe a surveillance system in C. elegans that monitors recombination intermediates and couples their formation to meiotic progression. Recombination intermediates are required to activate the system, which then delays further processing if crossover precursors are lacking on even one chromosome. The synaptonemal complex, a specialized, proteinaceous structure connecting homologous chromosomes, is stabilized in cis on chromosomes that receive a crossover and is destabilized on those lacking crossovers, a process that is dependent on the function of the polo-like kinase PLK-2. These results reveal a new layer of communication between crossover-committed intermediates and the synaptonemal complex that functions as a cis-acting, obligate, crossover-counting mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.