ReviewMayo Clinic proceedings2016
Myocardial Fibrosis in Athletes.
Review in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology.Journal of the American College of Cardiology · 2025Guideline
- Prevalence of abnormal cardiovascular magnetic resonance findings in recovered patients from COVID-19: a systematic review and meta-analysis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Pooled it
- Prevalence of Myocardial Fibrosis in Intensive Endurance Training Athletes: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2020Pooled it
- Effective of high-intensity interval training and moderate-intensity continuous training on body composition, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes: a randomized controlled trial.Frontiers in endocrinology · 2025Trial
- Dose-dependent effects and mechanisms of exercise-like stimulation on cardiac injury and contractile function: outcomes of the MICRO-ATHLETE study.Basic research in cardiology · 2026Article
- Masters Athletes With Abnormal Cardiovascular Findings: A Clinical Consensus Statement of the European Association of Preventive Cardiology of the ESC and the American College of Cardiology.Journal of the American College of Cardiology · 2026Article
- Masters athletes with abnormal cardiovascular findings: a clinical consensus statement of the European Association of Preventive Cardiology of the ESC and the American College of Cardiology.European heart journal · 2026Article
- Paroxysmal atrial fibrillation-like bursts in racehorses: do they affect speed and performance? A case control study.Journal of veterinary internal medicine · 2026Article
- Non-specific myocardial fibrosis in young competitive athletes: clinical significance and risk prediction by a powerful machine learning-based model.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Fragmented QRS complex in athletes' electrocardiogram: physiological adaptation or pathological sign? A scoping review.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Review
- T1 Mapping–derived Predictors of Cardiac Remodeling and Fibrosis in Athletes using Advanced Machine Learning TechniquesCurrent medical imaging · 2026Article
- A concise guide of contemporary cardiovascular imaging practices to differentiate athlete's heart in the gray zone.Heart failure reviews · 2025Review
- Impact of NSAIDs and endurance exercise on myocardial fibrosis and arrhythmogenesis in murine coxsackieviral myocarditis.Scientific reports · 2025Article
- Cardiovascular Remodeling and Potential Controversies in Master Endurance Athletes-A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Cardiac Effects of Prolonged Endurance Exercise in Young and Older Athletes.Scandinavian journal of medicine & science in sports · 2025Article
- The Pathophysiology of Cardiac Troponin Release and the Various Circulating Cardiac Troponin Forms-Potential Clinical Implications.Journal of clinical medicine · 2025Review
- Prediction of cardiac remodeling and myocardial fibrosis in athletes based on IVIM-DWI images.iScience · 2025Article
- Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence.Frontiers in pharmacology · 2025Review
- Prediction of Cardiac Remodeling and/or Myocardial Fibrosis Based on Hemodynamic Parameters of Vena Cava in Athletes.Current medical imaging · 2025Article
- Left Ventricular Hypertrabeculation (LVHT) in Athletes: A Negligible Finding?Medicina (Kaunas, Lithuania) · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial fibrosis (MF) is a common phenomenon in the late stages of diverse cardiac diseases and is a predictive factor for sudden cardiac death. Myocardial fibrosis detected by magnetic resonance imaging has also been reported in athletes. Regular exercise improves cardiovascular health, but there may be a limit of benefit in the exercise dose-response relationship. Intense exercise training could induce pathologic cardiac remodeling, ultimately leading to MF, but the clinical implications of MF in athletes are unknown. For this comprehensive review, we performed a systematic search of the PubMed and MEDLINE databases up to June 2016. Key Medical Subject Headings terms and keywords pertaining to MF and exercise (training) were included. Articles were included if they represented primary MF data in athletes. We identified 65 athletes with MF from 19 case studies/series and 14 athletic population studies. Myocardial fibrosis in athletes was predominantly identified in the intraventricular septum and where the right ventricle joins the septum. Although the underlying mechanisms are unknown, we summarize the evidence for genetic predisposition, silent myocarditis, pulmonary artery pressure overload, and prolonged exercise-induced repetitive micro-injury as contributors to the development of MF in athletes. We also discuss the clinical implications and potential treatment strategies of MF in athletes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.