ArticleCell2016
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
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Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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0cells of the map it votes in
109citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
What it found
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Who cites it
109 citing papers in PubMed, 188 citations in OpenAlex.
- The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026Review
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- Hypothalamic control of heart rate and body temperature by thyroid hormones.Reviews in endocrine & metabolic disorders · 2026Review
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- Overnutrition in mice impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations.The Journal of clinical investigation · 2026Article
- Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.Molecular metabolism · 2026Article
- Nuclear Receptor-Targeted Therapies: Reprogramming Metabolism with TRβ, ERRα, and LXR Modulators.Biomolecules · 2026Review
- Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice.GeroScience · 2026Article
- Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice.Obesity (Silver Spring, Md.) · 2026Article
- Pharmacotherapy in metabolic-dysfunction-associated steatotic liver disease: an updated review of the past, present and a promising future.Diabetology international · 2025Article
- Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis.Cell & bioscience · 2025Article
- Dual and Triple Gut Peptide Agonists on the Horizon for the Treatment of Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data.Current obesity reports · 2025Review
- Single-Molecule Insights into GPCR Conformational Landscapes.The Journal of membrane biology · 2025Review
- Role of serum fasting glucagon in hypothyroidism-related nonalcoholic fatty liver disease.Nutrition & metabolism · 2025Article
- Actions of thyroid hormones and thyromimetics on the liver.Nature reviews. Gastroenterology & hepatology · 2025Review
- The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP.Frontiers in endocrinology · 2025Review
- Why are we still in need for novel anti-obesity medications?The Lancet regional health. Europe · 2024Review
- Innovative Glucagon-based Therapies for Obesity.Journal of the Endocrine Society · 2024Review
- Adipose Tissue Plasticity: A Comprehensive Definition and Multidimensional Insight.Biomolecules · 2024Review
49 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 15 institutions in 6 countries.
Brian FinanInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Christoffer ClemmensenInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Zhimeng ZhuDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Kerstin StemmerInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Karine GauthierInstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA), École Normale Supérieure de Lyon, 69364 Lyon, France.
Luisa MüllerInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
Meri De AngelisMolecular EXposomics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
Kristin MorethGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Frauke NeffGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Diego Perez-TilveDivision of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA.
Katrin FischerInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Dominik LutterInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Miguel A Sánchez-GarridoInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Peng LiuInstitute of Comparative Molecular Endocrinology, University of Ulm, 89081 Ulm, Germany.
Jan TuckermannInstitute of Comparative Molecular Endocrinology, University of Ulm, 89081 Ulm, Germany.
Mohsen MalehmirDepartment of Pathology and Molecular Pathology, University Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
Marc E HealyDepartment of Pathology and Molecular Pathology, University Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
Achim WeberDepartment of Pathology and Molecular Pathology, University Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
Mathias HeikenwalderInstitute of Virology, Technische Universität München, 81675 Munich, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Martin JastrochInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Maximilian KleinertInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2200 Copenhagen, Denmark.
Sigrid JallInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Sara BrandtInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Frédéric FlamantInstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA), École Normale Supérieure de Lyon, 69364 Lyon, France.
Karl-Werner SchrammMolecular EXposomics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
Heike BiebermannInstitute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Berlin 13353, Germany.
Yvonne DöringDepartment of Medicine, Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, 80336, Munich, Germany; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance (MHA), 80336 Munich, Germany.
Christian WeberDepartment of Medicine, Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, 80336, Munich, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
Kirk M HabeggerComprehensive Diabetes Center and Department of Medicine-Endocrinology, Diabetes & Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Michaela KeuperInstitute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg 85764, Germany.
Vasily GelfanovDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Fa LiuCalibrium LLC, Carmel, IN 46032, USA.
Josef KöhrleInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin 13353, Germany.
Jan RozmanGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Helmut FuchsGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Valerie Gailus-DurnerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Martin Hrabě de AngelisGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Freising 85353, Germany.
Susanna M HofmannGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg 85764, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, München 80336, Germany.
Bin YangDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Matthias H TschöpInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de.
Richard DiMarchiDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA. Electronic address: rdimarch@indiana.edu.
Timo D MüllerInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Helmholtz Zentrum München · DETechnical University of Munich · DEIndiana University Bloomington · USDeutsches Diabetes-Zentrum e.V. · DEUniversity Hospital of Zurich · CHCharité - Universitätsmedizin Berlin · DEHeinrich Heine University Düsseldorf · DEUniversität Ulm · DECalifornia Institute for Biomedical Research · USCentre National de la Recherche Scientifique · FRÉcole Normale Supérieure de Lyon · FRGerman Centre for Cardiovascular Research · DELudwig-Maximilians-Universität München · DEUniversity of Alabama at Birmingham · USUniversity of Cincinnati Medical Center · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucagon and thyroid hormone (T
Indexed as
AnimalsAtherosclerosisBody WeightBone and BonesChemical EngineeringCholesterolDiabetes Mellitus, Type 2Disease Models, AnimalDrug CombinationsDrug Delivery SystemsDrug SynergismGlucagonHyperglycemiaLiverMetabolic DiseasesMiceCholesterolDrug CombinationsGlucagonTriiodothyronineco-agonistconjugatedyslipidemiaglucagonNASHobesitypolypharmacologythyroid hormone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.