ArticleThe Journal of allergy and clinical immunology2016
Pathways through which asthma risk factors contribute to asthma severity in inner-city children.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01383941 (Asthma Phenotypes in the Inner City), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Asthma Phenotypes in the Inner City (ICAC-19)
Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- Cumulative genetic risk for asthma contributes to disease severity in children with asthma.The journal of allergy and clinical immunology. Global · 2026Article
- Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with Asthma living in Urban Environments.medRxiv : the preprint server for health sciences · 2025Article
- Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone-A real-world study.Clinical and translational allergy · 2025Article
- Review
- Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.The Journal of allergy and clinical immunology · 2023Article
- A recombinant Der p 1-specific allergen-toxin demonstrates superior killing of allergen-reactive IgGImmunotherapy advances · 2023Article
- Allergic Asthma in the Era of Personalized Medicine.Journal of personalized medicine · 2022Review
- Maintenance of Asthma Control in Adolescents with Severe Asthma After Transitioning to a Specialist Adult Centre: A French Cohort Experience.Journal of asthma and allergy · 2022Article
- A Current Perspective of Allergic Asthma: From Mechanisms to Management.Handbook of experimental pharmacology · 2022Review
- Smartphone App for monitoring Asthma in children and adolescents.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Defining pediatric asthma: phenotypes to endotypes and beyond.Pediatric research · 2021Review
- Atopy and pulmonary function among healthy-weight and overweight/obese children with asthma.Pediatric pulmonology · 2021Article
- Association between Peak Expiratory Flow Rate and Exposure Level to Indoor PM2.5 in Asthmatic Children, Using Data from the Escort Intervention Study.International journal of environmental research and public health · 2020Article
- Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study.Allergy, asthma & immunology research · 2020Article
- Next-generation care pathways for allergic rhinitis and asthma multimorbidity: a model for multimorbid non-communicable diseases-Meeting Report (Part 1).Journal of thoracic disease · 2019Article
- Inner-City Asthma in Children.Clinical reviews in allergy & immunology · 2019Review
- Association of secondhand smoke exposure with asthma symptoms, medication use, and healthcare utilization among asthmatic adolescents.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Article
- Rhinitis in children and adolescents with asthma: Ubiquitous, difficult to control, and associated with asthma outcomes.The Journal of allergy and clinical immunology · 2019Article
- Expression of corticosteroid-regulated genes by PBMCs in children with asthma.The Journal of allergy and clinical immunology · 2019Article
Corrections and comments
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- Commented on byReply.2017
Authors and funding
21 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundPathway analyses can be used to determine how host and environmental factors contribute to asthma severity.
objectiveTo investigate pathways explaining asthma severity in inner-city children.
methodsOn the basis of medical evidence in the published literature, we developed a conceptual model to describe how 8 risk-factor domains (allergen sensitization, allergic inflammation, pulmonary physiology, stress, obesity, vitamin D, environmental tobacco smoke [ETS] exposure, and rhinitis severity) are linked to asthma severity. To estimate the relative magnitude and significance of hypothesized relationships among these domains and asthma severity, we applied a causal network analysis to test our model in an Inner-City Asthma Consortium study. Participants comprised 6- to 17-year-old children (n = 561) with asthma and rhinitis from 9 US inner cities who were evaluated every 2 months for 1 year. Asthma severity was measured by a longitudinal composite assessment of day and night symptoms, exacerbations, and controller usage.
resultsOur conceptual model explained 53.4% of the variance in asthma severity. An allergy pathway (linking allergen sensitization, allergic inflammation, pulmonary physiology, and rhinitis severity domains to asthma severity) and the ETS exposure pathway (linking ETS exposure and pulmonary physiology domains to asthma severity) exerted significant effects on asthma severity. Among the domains, pulmonary physiology and rhinitis severity had the largest significant standardized total effects on asthma severity (-0.51 and 0.48, respectively), followed by ETS exposure (0.30) and allergic inflammation (0.22). Although vitamin D had modest but significant indirect effects on asthma severity, its total effect was insignificant (0.01).
conclusionsThe standardized effect sizes generated by a causal network analysis quantify the relative contributions of different domains and can be used to prioritize interventions to address asthma severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.