Evidence map›Paper›PMID 27718413›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2016

Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration.

Miguel Quiliano, Adela Mendoza, Kim Y Fong, Adriana Pabón, Nathan E Goldfarb, Isabelle Fabing, Ariane Vettorazzi, Adela López de Cerain, Ben M Dunn, Giovanny Garavito and 5 more

Abstract read
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Proposition ofCombinatorial chemistry & high throughput screening · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Miguel QuilianoDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain; Institute of Tropical Health (ISTUN), University of Navarra, Pamplona, 31008, Spain.
Adela MendozaDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain.
Kim Y FongDepartment of Chemistry, Vanderbilt University, Station B 351822, Nashville, TN 37235, USA.
Adriana PabónGrupo Malaria, Universidad de Antioquía, Medellín, Colombia.
Nathan E GoldfarbDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA.
Isabelle FabingLaboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique SPCMIB - UMR5068, CNRS - Université Paul Sabatier, 118, route de Narbonne, 31062, Toulouse Cedex 09, France.
Ariane VettorazziDepartment of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain.
Adela López de CerainDepartment of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain.
Ben M DunnDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA.
Giovanny GaravitoUniversidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Farmacia (DFUNC), Grupo de investigación FaMeTra (Farmacología de la Medicina tradicional y popular), Carrera 30 45-03, Bogotá D.C., Colombia.
David W WrightDepartment of Chemistry, Vanderbilt University, Station B 351822, Nashville, TN 37235, USA.
Eric DeharoUMR 152 PHARMA-DEV, Université Toulouse, IRD, UPS, 31062, Toulouse, France.
Silvia Pérez-SilanesDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain; Institute of Tropical Health (ISTUN), University of Navarra, Pamplona, 31008, Spain.
Ignacio AldanaDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain; Institute of Tropical Health (ISTUN), University of Navarra, Pamplona, 31008, Spain.
Silvia GalianoDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, 31008, Spain; Institute of Tropical Health (ISTUN), University of Navarra, Pamplona, 31008, Spain. Electronic address: sgaliano@unav.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identification of compounds 22 and 23 with significant in vitro antiplasmodial activity against drug sensitive (D6 IC

Indexed as

Amino AlcoholsAnimalsAntimalarialsDisease Models, AnimalDrug-Related Side Effects and Adverse ReactionsInhibitory Concentration 50Malaria, FalciparumMicePlasmodium falciparumStructure-Activity RelationshipSurvival AnalysisTreatment OutcomeAmino AlcoholsAntimalarialsAntimalarialAntiplasmodialArylamino alcoholHemozoin inhibitionMannich reactionPlasmepsin II enzyme

Identifiers

PMID27718413
PMCPMC5061469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.