ArticleCytometry. Part B, Clinical cytometry2017
The newborn human NK cell repertoire is phenotypically formed but functionally reduced.
Article in Cytometry. Part B, Clinical cytometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Serious neurological adverse events in immunocompetent children and adolescents caused by viral reactivation in the years following varicella vaccination.Reviews in medical virology · 2024Pooled it
- Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.Cell death & disease · 2026Review
- Immune correlates of HIV-1 rebound during broadly neutralizing antibody treatment in young children.The Journal of clinical investigation · 2026Article
- Immune system ontogeny-a subtle evolution to perfection.Frontiers in aging · 2026Review
- Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants.Nature communications · 2024Article
- Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.bioRxiv : the preprint server for biology · 2023Article
- In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection.The Journal of infectious diseases · 2022Article
- Breastfeeding in the context of the COVID-19 pandemic: A discussion paper.Journal of neonatal nursing : JNN · 2022Review
- Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Immune Recovery Following Autologous Hematopoietic Stem Cell Transplantation in HIV-Related Lymphoma Patients on the BMT CTN 0803/AMC 071 Trial.Frontiers in immunology · 2021Article
- The Spectrum of Clinical, Immunological, and Molecular Findings in Familial Hemophagocytic Lymphohistiocytosis: Experience From India.Frontiers in immunology · 2021Article
- Extreme prematurity and sepsis strongly influence frequencies and functional characteristics of circulating γδ T and natural killer cells.Clinical & translational immunology · 2021Article
- COVID-19 in babies: Knowledge for neonatal care.Journal of neonatal nursing : JNN · 2020Review
- Redirection of Cord Blood T Cells and Natural Killer Cells for Elimination of Autologous HIV-1-Infected Target Cells Using Bispecific DART® Molecules.Frontiers in immunology · 2020Article
- CXCR6Frontiers in immunology · 2019Article
- Diversification of human NK cells: Lessons from deep profiling.Journal of leukocyte biology · 2018Review
- The Broad Spectrum of Human Natural Killer Cell Diversity.Immunity · 2017Review
- The road ahead: Implementing mass cytometry in clinical studies, one cell at a time.Cytometry. Part B, Clinical cytometry · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInfection is a leading cause of death worldwide in babies under 1 month of age. Better vaccines and therapeutics are desperately needed for this vulnerable population.
methodsBecause newborns rely heavily on the innate immune system, we evaluated cell phenotype and function of some of the earliest cellular responders during infection, natural killer (NK) cells. We used mass cytometry to provide a comprehensive comparison of NK cells from umbilical cord blood and adult peripheral blood.
resultsIn unsupervised analyses, including viSNE and principal component analysis, the structure of the cord blood and adult NK cell repertoires are highly similar, distinguishable mainly by maturity-related markers expressed on rare subpopulations of cells. However, in functional analyses, cord blood NK cells show reduced degranulation and cytokine production following target recognition, as well as antibody-dependent cell-mediated cytotoxicity and apoptosis induction in targets.
conclusionsThese findings show that the structure of the NK cell repertoire is intact at birth, suggesting great potential for vaccine and therapeutic strategies targeting this cell population. © 2016 International Clinical Cytometry Society.
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