Evidence map›Paper›PMID 27718238›Full record

ArticleAllergy2017

Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.

A R Mathers, C D Carey, M E Killeen, J A Diaz-Perez, S R Salvatore, F J Schopfer, B A Freeman, L D Falo

Open access · greenAbstract read
In one paragraph

Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Beyond Avoidance: Advanced Therapies for Contact Dermatitis.The journal of allergy and clinical immunology. In practice · 2024
    Review
  2. Review
  3. Nitro-oleic acid regulates T cell activation through post-translational modification of calcineurin.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. mTORC2 deficiency in cutaneous dendritic cells potentiates CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A R MathersDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6931-8605
C D CareyDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
M E KilleenDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
J A Diaz-PerezDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
S R SalvatoreDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
F J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
B A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
L D FaloDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

Therapuetic Immune Targeting of EphA2 Expressed by Melanoma & Its Tumor-AssociateP50CA121973 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIRKWOOD, JOHN MUNN · 2008 to 2018
$22.9M
FLUORESCENT PROBES &IMAGING FOR NETWORKS &PATHWAY(RMI)U54RR022241 · NCRR · MELLON PITTS CORPORATION (MPC CORP) · PI WAGGONER, ALAN S. · 2005 to 2011
$19.9M
Redox Transduction of Nitric Oxide SignalingR37HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2008 to 2017
$5.2M
Anti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9M
Manipulating Cutaneous Neuroimmunity to Treat Contact DermatitisR01AR068249 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FALO, LOUIS D, LARREGINA, ADRIANA T · 2015 to 2019
$2.1M
The Immunoregulatory Effects of Electrophilic Fatty Acids on PsoriasisR01AR066548 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATHERS, ALICIA R · 2015 to 2019
$1.7M
NCI NIH HHS P50 CA121973NCRR NIH HHS U54 RR022241NHLBI NIH HHS R01 HL132550NHLBI NIH HHS R37 HL058115NIAMS NIH HHS R01 AR066548NIAMS NIH HHS R01 AR068249
6 · The paper itself

Abstract

backgroundReactions between nitric oxide (NO), nitrite (NO2-), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO

methodsWe evaluated the effect of OA-NO

resultsWe found that subcutaneous (SC) OA-NO

conclusionOverall, these results support the development of OA-NO

Indexed as

AnimalsBiomarkersDermatitis, Allergic ContactDisease Models, AnimalFatty AcidsFemaleGene Expression ProfilingMiceNeovascularization, PathologicNitric OxideNitritesT-Lymphocyte SubsetsBiomarkersFatty AcidsNitric OxideNitritesallergic contact dermatitiscontact hypersensitivityelectrophilic fatty acidsnitro-oleic acidT regulatory cells

Identifiers

PMID27718238
PMCPMC5352476
OpenAlexW2528806584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.