ArticleDevelopmental medicine and child neurology2017
Auditory toxicity in late preterm and term neonates with severe jaundice.
Article in Developmental medicine and child neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- From clusters to clinical rules: unsupervised machine learning identifies four newborn hearing phenotypes with bedside risk stratification.BMC pediatrics · 2026Article
- Unbound free fatty acids from intralipid displace bilirubin from albumin, comparable to sulfisoxazole.Pediatric research · 2026Article
- Unbound bilirubin and risk of severe neurodevelopmental impairment in extremely low birthweight newborns.Pediatric research · 2025Article
- Factors Affecting the Relationship Between Total and Unbound Bilirubin in Preterm and Term Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- The Effect of Intravenous Albumin Administration Before Exchange Transfusion in Infants With Hyperbilirubinemia: A Meta-Analysis.Health science reports · 2025Review
- Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study.Heliyon · 2024Article
- Demystifying non-invasive approaches for screening jaundice in low resource settings: a review.Frontiers in pediatrics · 2023Review
- A Study of JCIH (Joint Commission on Infant Hearing) Risk Factors for Hearing Loss in Babies of NICU and Well Baby Nursery at a Tertiary Care Center.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Bile pigments in emergency and critical care medicine.European journal of medical research · 2022Review
- Unbound bilirubin measurements in term and late-preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Effect of Hyperbilirubinemia on Medial Olivocochlear System in Newborns.The journal of international advanced otology · 2019Article
- Unbound bilirubin measurements by a novel probe in preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Article
- Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders.Pediatric research · 2019Review
- Bilirubin binding in jaundiced newborns: from bench to bedside?Pediatric research · 2018Review
- Risk Factors for Hearing Loss and Its Prevalence in Neonates Older than 6 Months with History of Hospitalization in Intensive Care Unit.Iranian journal of child neurology · 2018Article
- Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants.The Journal of pediatrics · 2018Observational
- Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia.Pediatrics · 2017Observational
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
aimJaundice may cause auditory toxicity (auditory neuropathy and hearing loss). However, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. We compared TSB, bilirubin:albumin molar ratio (BAMR), and unbound bilirubin for their association with auditory toxicity in neonates with severe jaundice (TSB ≥342μmol/L, or that met exchange transfusion).
methodNeonates greater or equal to 34 weeks gestational age with severe jaundice during the first 2 postnatal weeks were eligible for prospective cohort study, unless they had craniofacial malformations, chromosomal disorders, toxoplasmosis, other infections, rubella, cytomegalovirus, herpes simplex infections, surgery, or family history of congenital deafness.
resultsTwenty-eight out of 100 neonates (mean gestational age 37.4wks; 59 males, 41 females) had auditory toxicity. Peak unbound bilirubin, but not peak TSB and BAMR, was associated with auditory toxicity (p<0.05) in neonates with severe (TSB <427.5μmol/L) and extreme hyperbilirubinemia (TSB ≥427.5μmol/L). Area under the receiver operating characteristic curve for unbound bilirubin (0.78) was significantly greater (p=0.03) than TSB (0.54) among neonates with severe but not extreme hyperbilirubinemia.
interpretationUnbound bilirubin is more strongly associated with auditory toxicity than TSB and/or BAMR in greater or equal to 34 weeks gestational age neonates with severe jaundice. Unbound bilirubin is a better predictor than TSB in neonates with severe hyperbilirubinemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.