Evidence map›Paper›PMID 27718137›Full record

Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2017

Short-term surgical outcomes from a phase III study of laparoscopy-assisted versus open distal gastrectomy with nodal dissection for clinical stage IA/IB gastric cancer: Japan Clinical Oncology Group Study JCOG0912.

Hitoshi Katai, Junki Mizusawa, Hiroshi Katayama, Masakazu Takagi, Takaki Yoshikawa, Takeo Fukagawa, Masanori Terashima, Kazunari Misawa, Shin Teshima, Keisuke Koeda and 6 more

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 216 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 13 pooled it
24.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710758 narecruitingnot on this mapstarted 2021, after this paper: background citation

Prospective Randomized Controlled Multicenter Clinical Trial For Comparison Of Long-term Outcomes Between Laparoscopic And Open Total Gastrectomy In Patients With Locally Advanced Gastric Cancer

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2021 to 2028Enrolled1,018ConditionsStomach NeoplasmsArmsLaparoscopic total gastrectomy, Open total gastrectomy
NCT05707338 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Short-term Outcomes of Laparoscopic Versus Open Gastrectomy With Lymph Node Dissection for Early Gastric Cancer :a Randomized Controlled Study

TypeinterventionalSponsorSohag UniversityRan2023 to 2025Enrolled40ConditionsEarly Gastric CancerArmsGastrectomy with lymph node dissection
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 13 syntheses or guidelines pooled it, 383 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  6. [Evidence in minimally invasive oncological gastric surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
    Pooled it
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  11. Laparoscopic versus open gastrectomy for gastric cancer.World journal of surgical oncology · 2020
    Pooled it
  12. Pooled it
  13. Guideline
  14. Trial
  15. Short-term outcomes of preoperative computed tomography angiography versus standard assessment in patients with BMI ≥ 25.0 kg/mGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Trial
  16. Morbidity and quality of life of totally laparoscopic versus laparoscopy-assisted distal gastrectomy for early gastric cancer: a multi-center prospective randomized controlled trial (CKLASS01).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Trial
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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 1 country.

Hitoshi KataiGastric Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, chuo-ku, Tokyo, 104-0045, Japan. hkatai@ncc.go.jp.
Junki MizusawaJapan Clinical Oncology Group Data Center/Operations Office, National Cancer Center, Tokyo, Japan.
Hiroshi KatayamaJapan Clinical Oncology Group Data Center/Operations Office, National Cancer Center, Tokyo, Japan.
Masakazu TakagiDepartment of Gastroenterological Surgery, Shizuoka General Hospital, Shizuoka, Japan.
Takaki YoshikawaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan.
Takeo FukagawaGastric Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, chuo-ku, Tokyo, 104-0045, Japan.
Masanori TerashimaDivision of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Kazunari MisawaDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Shin TeshimaDepartment of Surgery, National Hospital Organization, Sendai Medical Center, Sendai, Japan.
Keisuke KoedaDepartment of Surgery, Iwate Medical University, Morioka, Japan.
Souya NunobeDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, Japan.
Norimasa FukushimaDepartment of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Takashi YasudaDepartment of Gastroenterological Surgery, Hyogo Cancer Center, Akashi, Japan.
Yoshito AsaoDepartment of Gastroenterological Surgery, Tenri Hospital, Tenri, Japan.
Yoshiyuki FujiwaraDepartment of Gastroenterological Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Mitsuru SasakoDivision of Upper Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Japan Clinical Cancer Research Organization · JPAichi Cancer Center · JPHyogo Medical University · JPHyogo Prefectural Cancer Center · JPIwate Medical University · JPKanagawa Prefectural Hospital Organization · JPOsaka Medical Center for Cancer and Cardiovascular Diseases · JPSendai Medical Center · JPShizuoka Cancer Center · JPShizuoka General Hospital · JPTenri Hospital · JPThe Cancer Institute Hospital · JPYamagata Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsNo confirmatory randomized controlled trials (RCTs) have evaluated the efficacy of laparoscopy-assisted distal gastrectomy (LADG) compared with open distal gastrectomy (ODG). We performed an RCT to confirm that LADG is not inferior to ODG in efficacy.

methodsWe conducted a multi-institutional RCT. Eligibility criteria included histologically proven gastric adenocarcinoma in the middle or lower third of the stomach, clinical stage I tumor. Patients were preoperatively randomized to ODG or LADG. This study is now in the follow-up stage. The primary endpoint is relapse-free survival (RFS) and the primary analysis is planned in 2018. Here, we compared the surgical outcomes of the two groups. This trial was registered at the UMIN Clinical Trials Registry as UMIN000003319.

resultsBetween March 2010 and November 2013, 921 patients (LADG 462, ODG 459) were enrolled from 33 institutions. Operative time was longer in LADG than in ODG (median 278 vs. 194 min, p < 0.001), while blood loss was smaller (median 38 vs. 115 ml, p < 0.001). There was no difference in the overall proportion with in-hospital grade 3-4 surgical complications (3.3 %: LADG, 3.7 %: ODG). The proportion of patients with elevated serum AST/ALT was higher in LADG than in ODG (16.4 vs. 5.3 %, p < 0.001). There was no operation-related death in either arm.

conclusionsThis trial confirmed that LADG was as safe as ODG in terms of adverse events and short-term clinical outcomes. LADG may be an alternative procedure in clinical IA/IB gastric cancer if the noninferiority of LADG in terms of RFS is confirmed.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overDisease-Free SurvivalFemaleGastrectomyHumansJapanLaparoscopyLymph Node ExcisionMaleMiddle AgedStomach NeoplasmsTreatment OutcomeClinical trialGastrectomyGastric cancerLaparoscopic surgeryPhase III

Identifiers

PMID27718137
OpenAlexW2529294648

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.