ArticleEnvironmental science and pollution research international2017
Association between inflammation processes, DNA damage, and exposure to environmental pollutants.
Article in Environmental science and pollution research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Toxicological Effects of Air Pollutants on Human Airway Cell Models Using Air-liquid Interface Systems: A Systematic Review.Current environmental health reports · 2025Pooled it
- Does air pollution play a role in infertility?: a systematic review.Environmental health : a global access science source · 2017Pooled it
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- Climate Change and Reproductive Health.Endocrine reviews · 2025Review
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Associations of exposure to polycyclic aromatic hydrocarbons with hearing in U.S. Adults.Scientific reports · 2025Article
- Environmental Challenges in Southern Brazil: Impacts of Pollution and Extreme Weather Events on Biodiversity and Human Health.International journal of environmental research and public health · 2025Review
- Article
- Air Pollution and Primary DNA Damage among Zagreb (Croatia) Residents: A Cross-Sectional Study.Journal of xenobiotics · 2024Article
- Human Biomonitoring of Selected Hazardous Compounds in Portugal: Part I-Lessons Learned on Polycyclic Aromatic Hydrocarbons, Metals, Metalloids, and Pesticides.Molecules (Basel, Switzerland) · 2021Review
- Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.Environment international · 2018Article
- Are metals and pyrene levels additional factors playing a pivotal role in air pollution-induced inflammation in taxi drivers?Toxicology research · 2018Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental exposure to pollutants, especially polycyclic aromatic hydrocarbons (PAHs), could lead to carcinogenesis development. However, there is a gap on the mechanisms involved in this effect. Therefore, the aim of this study was to investigate the potential relationship between exposure to environmental air pollution and inflammation process in DNA damage in taxi drivers. This study included 45 taxi drivers and 40 controls; non-smokers composed both groups. Biological monitoring was performed through quantification of urinary 1-hydroxypyrene (1-OHP). ICAM-1 (CD54) expression, NTPDase activity, inflammatory cytokine (IL-1β, IL-6, IL-10, TNF-α and IFN-γ) levels, and comet and micronucleus assays were evaluated. The results demonstrated that 1-OHP levels, ICAM-1 expression, NTPDase activity, and DNA damage biomarkers (% tail DNA and micronucleus frequency) were increased in taxi drivers compared to the control group (p < 0.01). Moreover, significant associations were found between 1-OHP levels and ICAM-1 expression, % tail DNA, and micronucleus frequency (p < 0.05). Besides, pro-inflammatory cytokine levels were positively correlated to % tail DNA and micronucleus frequency (p < 0.001). Our findings suggest an important association between environmental exposure to air pollution with increase of ICAM-1 expression and NTPDase activity in taxi drivers. Additionally, the multiple regression linear-analysis demonstrated association between IL-6 and DNA damage. Thus, the present study has provided important evidence that, in addition to environmental exposure to air pollutants, the inflammation process may contribute to DNA damage.
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Registered trials
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