ArticleDigestive diseases and sciences2016
Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia.
Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations.Journal of gastroenterology and hepatology · 2026Pooled it
- From data mining to experimental validation: ST36 and CV12 as core acupoint combination for acupuncture in functional dyspepsia.Frontiers in medicine · 2026Article
- Ganhai Weikang Capsules ameliorate functional dyspepsia in rats by modulating gut microbiota and host metabolic homeostasis.Frontiers in pharmacology · 2026Article
- The Association between Functional Dyspepsia and Metabolic Syndrome-The State of the Art.International journal of environmental research and public health · 2024Review
- Correlation between anxiety and decreased quality of life in patients with non-esophageal eosinophilic gastrointestinal diseases.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight - An integrated bibliometric and science mapping approach.Frontiers in neuroscience · 2023Review
- A review of neuroendocrine immune system abnormalities in IBS based on the brain-gut axis and research progress of acupuncture intervention.Frontiers in neuroscience · 2023Review
- Central nervous system stimulants promote nerve cell death under continuous hypoxia.Human cell · 2022Article
- Immune Activation in Functional Dyspepsia: Bystander Becoming the Suspect.Frontiers in neuroscience · 2022Review
- The Role of Leaky Gut in Functional Dyspepsia.Frontiers in neuroscience · 2022Review
- Overexpression of microRNA-211 in Functional Dyspepsia via Downregulation of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) by Increasing Phosphorylation of p38 MAPK Pathway.Canadian journal of gastroenterology & hepatology · 2022Article
- Nutraceuticals and Enteric Glial Cells.Molecules (Basel, Switzerland) · 2021Review
- Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.Human cell · 2021Article
- Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease.International journal of molecular sciences · 2020Review
- Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia.Digestive diseases and sciences · 2020Article
- Acute stress disrupts intestinal homeostasis via GDNF-RET.Cell proliferation · 2020Article
- Review
- Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine.Drug design, development and therapy · 2020Article
- Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center.Journal of gastroenterology · 2019Review
- Gastroparesis and Functional Dyspepsia: A Blurring Distinction of Pathophysiology and Treatment.Journal of neurogastroenterology and motility · 2019Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with functional dyspepsia (FD), mild duodenal inflammation correlates with increased mucosal permeability. Enteric glial cells can produce glial cell line-derived neurotrophic factor (GDNF) to repair disrupted epithelial barrier function.
aimsWe examined the role of duodenal GDNF in FD pathophysiology and its association with dyspeptic symptoms.
methodsDuodenal biopsies taken from FD patients and control subjects were used for analysis. GDNF protein expression and localization were examined. Cellular infiltration of eosinophils and mast cells was measured. We also examined the intercellular space between the adjacent epithelial cells at the apical junction complex using transmission electron microscopy.
resultsIn FD patients, expression of GDNF protein was significantly increased compared with controls, 107.3 (95.3-136.7) versus 49.3 (38.0-72.6) pg/mg protein (median (interquartile range), p = 0.006), respectively. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells. The number of eosinophils was significantly greater in FD patients than in controls, 1039 (923-1181) versus 553 (479-598) cells/mm
conclusionsIncreased expression of duodenal GDNF might be involved in FD pathophysiology and symptom perception.
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