ArticleInternational ophthalmology2017
The assessment of peripapillary retinal nerve fiber layer and macular ganglion cell layer changes in obese children: a cross-sectional study using optical coherence tomography.
Article in International ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Inner retinal structure and intraocular pressure in children with obesity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Association Between Pediatric Obesity and Ocular Structural Parameters: A Cross-Sectional Study.Children (Basel, Switzerland) · 2026Article
- Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases.Nature communications · 2025Article
- Clinical Relevance of Choroidal Thickness in Obese and Healthy Children: A Machine Learning Study.Turkish journal of ophthalmology · 2023Article
- Analysis of Plasma Metabolic Profile on Ganglion Cell-Inner Plexiform Layer Thickness With Mortality and Common Diseases.JAMA network open · 2023Article
- Obesity-induced ocular changes in children and adolescents: A review.Frontiers in pediatrics · 2023Review
- Optical Coherence Tomography Analysis of Retinal Layers in Celiac Disease.Journal of clinical medicine · 2022Article
- Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory MarkersJournal of clinical research in pediatric endocrinology · 2020Article
- Thinning of Macular Neuroretinal Layers Contributes to Sleep Disorder in Patients With Type 2 Diabetes Without Clinical Evidences of Neuropathy and Retinopathy.Frontiers in endocrinology · 2020Article
- An Assessment of Retinal Nerve Fiber Layer Thickness in Non-Diabetic Obese Children and Adolescents.Journal of clinical research in pediatric endocrinology · 2018Article
- Biometric Parameters and Ganglion Cell Measurements in Children of Patients with Primary Angle-closure Glaucoma.Journal of current glaucoma practiceArticle
- Inner retinal thickness and optic disc measurements in obese children and adolescents.Arquivos brasileiros de oftalmologiaArticle
- Peripapillary Retinal Nerve Fiber Layer Thickness and its Ocular and Systemic Determinants in an Elderly Population: A Population-Based Study.Journal of current ophthalmologyArticle
- Microvascular changes in obese adults detected by Optical Coherence Tomography Angiography.Romanian journal of ophthalmologyArticle
- The impact of obesity on ocular hemodynamics and choroidal thickness.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the relationship between the obesity and optical coherence tomography (OCT) parameters.
methodsWe studied 54 obese and 33 non-obese children and adolescents. Obesity was defined as BMI higher than 95th percentile (BMI SDS > 1.64). OCT measurements were performed in all participants. Anthropometric and biochemical variables were compared with OCT parameters of 174 eyes.
resultsIn obese children, in all quadrants retinal nerve fiber layer (RNFL) thicknesses were significantly lower than non-obese children, and also ganglion cell-inner plexiform layer thicknesses in inferior and superiortemporal quadrants were significantly lower in the obese group. BMI SDS, insulin, HOMA-IR and triglyceride levels were negatively correlated with RNFL thickness, significantly (r = -0.386, p < 0.001; r = -0.229, p = 0.002; r = -0.188, p = 0.013; and r = -0.301, p = 0.000; respectively) in all subjects.
conclusionsThinning in RNFL was detected in normal-looking discs of obese children, and this thinning negatively correlated with BMI SDS. Further studies including large series are needed to clarify whether obesity has an effect on RNFL thickness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.