ArticleJournal of cardiac failure2016
Mode of Death in Octogenarians Treated With Cardiac Resynchronization Therapy.
Article in Journal of cardiac failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Left Bundle Branch Area Pacing in Older Patients: A New Opportunity?Life (Basel, Switzerland) · 2026Review
- Outcomes following cardiac resynchronisation therapy in older people.Age and ageing · 2023Article
- Heart Failure in Older Adults: Medical Management and Advanced Therapies.Geriatrics (Basel, Switzerland) · 2022Review
- Safety of mechanical lung vibrator and high-frequency chest wall oscillation in patients with cardiac implantable electronic device.Clinical cardiology · 2021Article
- Modes of death in heart failure according to age, sex and left ventricular ejection fraction.Internal and emergency medicine · 2021Article
- Implantable Cardiac Electronic Devices in the Elderly Population.Arrhythmia & electrophysiology review · 2019Review
- Modified frailty as a novel factor in predicting the response to cardiac resynchronization in the elderly population.Clinical interventions in aging · 2019Article
- Facility-Level Variation and Clinical Outcomes in Use of Cardiac Resynchronization Therapy With and Without an Implantable Cardioverter-Defibrillator.Circulation. Cardiovascular quality and outcomes · 2018Observational
- Cardiac Resynchronization Therapy in Older Patients: Age Is Just a Number, and Yet ….Journal of cardiac failure · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac resynchronization therapy (CRT) improves morbidity and mortality in heart failure with reduced ejection fraction (HFrEF) and electrical dyssynchrony. CRT patients in clinical practice are older compared with clinical trials.
objectiveTo investigate clinical response, reverse remodeling, outcome, and mode of death in octogenarians receiving CRT.
methodsBaseline characteristics, change in New York Heart Association (NYHA) functional class, reverse ventricular remodeling, heart failure readmissions, all-cause mortality, and mode of death were evaluated in CRT patients with comparison between octogenarians and nonoctogenarians. In addition, annual mortality rates of octogenarians undergoing CRT were compared with age-matched control subjects from the general population with the use of national actuarial tables.
resultsA total of 686 patients, including 178 octogenarians (26%), were followed for 38 ± 22 months. Octogenarians exhibited a similar change in NYHA functional class (P = .640), left ventricular ejection fraction increase (P = .796), and decrease in end-diastolic (P = .441) and end-systolic (P = .312) diameter compared with their younger counterparts undergoing CRT. Octogenarians had a higher all-cause mortality risk (P < .001), but heart failure readmission risk did not differ (hazard ratio 0.916, 95% confidence interval 0.638-1.313; P = .632). A higher proportion of noncardiac deaths was observed in octogenarians (74%) versus younger patients (50%; P = .022), with worsening heart failure rather than malignant tachyarrhythmia being the main cardiac cause of death. Compared with an age-matched sample from the general population, octogenarians receiving CRT had an equivalent annual mortality rate (log-rank test: P = .444).
conclusionsOctogenarians retain the ability to mount a significant symptomatic and ventricular remodeling response after CRT, resulting in survival similar to the general age-matched population.
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