Evidence map›Paper›PMID 27717671›Full record

ArticleTrends in molecular medicine2016

Tuft Cells: New Players in Colitis.

Shaun P Steele, Stephanie J Melchor, William A Petri

Abstract read
In one paragraph

Article in Trends in molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Gut microbes
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shaun P SteeleDepartment of Medicine, Division of Infectious Disease, University of Virginia, Charlottesville, VA 22908, USA.
Stephanie J MelchorDepartment of Medicine, Division of Infectious Disease, University of Virginia, Charlottesville, VA 22908, USA.
William A PetriDepartment of Medicine, Division of Infectious Disease, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: wap3g@virginia.edu.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Role of Type 2 Immunity in Innate Protection from C. difficileR01AI124214 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2016 to 2026
$5.4M
Role of IL-23 in the Immunopathogenesis of C. difficile colitisR21AI114734 · NIAID · UNIVERSITY OF VIRGINIA · PI PETRI, WILLIAM A · 2015 to 2016
$422k
NIAID NIH HHS R01 AI124214NIAID NIH HHS R21 AI114734NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI007496
6 · The paper itself

Abstract

A recent surge of interest in tuft cells, which are chemosensory intestinal epithelial cells, has uncovered new functional roles for these cells in colorectal cancer, metabolic signaling, and type 2 immunity. Here, we explore emerging evidence suggesting that tuft cells are critical for protection during enteric infections and inflammatory responses.

Indexed as

AnimalsClostridioides difficileColitisEnterocolitis, PseudomembranousEpithelial CellsHelminthiasisHelminthsHumansImmunity, InnateIntestinal MucosaIntestinesSignal Transduction

Identifiers

PMID27717671
PMCPMC5159242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.