ArticleBrain stimulation
Direct Current Stimulation Alters Neuronal Input/Output Function.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Towards optimized methodological parameters for maximizing the behavioral effects of transcranial direct current stimulation.Frontiers in human neuroscience · 2024Pooled it
- Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020Pooled it
- Transcranial direct current stimulation enhances delayed retention after 5 days of lower-limb motor skill learning.The Journal of physiology · 2026Trial
- Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure.Journal of visualized experiments : JoVE · 2021Trial
- Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study.Scientific reports · 2019Trial
- No improvement in maximum jumping height in experienced and less experienced jumpers following a single session of transabdominal, transcutaneous spinal anodal direct current stimulation.Frontiers in physiology · 2026Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Increase in Ia Afferent Synaptic Excitation of SOD1 G93A Mouse Motoneurons by 2-Week Anodal Trans-Spinal Direct Current Stimulation Does Not Ameliorate the Cellular Burden of the Disease.The European journal of neuroscience · 2025Article
- Ionic Direct Current Enables Millimeter- and Millisecond-Scale Cortical Gain Control in vivo.bioRxiv : the preprint server for biology · 2025Article
- EFMouse: A toolbox to model stimulation-induced electric fields in the mouse brain.PLoS computational biology · 2025Article
- Computational Optimization of Spinal Cord Stimulation for Dorsal Horn Interneuron Polarization.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.Communications biology · 2025Article
- Effects of dendritic CaJournal of computational neuroscience · 2025Article
- Understanding the effects of transcranial direct current stimulation on the neurovascular unit: a narrative review.Frontiers in neuroscience · 2025Review
- Optimising transcranial direct current stimulation application for the enhancement of exercise performance: a review.Frontiers in physiology · 2025Review
- Dose-response of tDCS effects on motor learning and cortical excitability: A preregistered study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.Journal of neural engineering · 2024Article
- Machine learning-optimized non-invasive brain stimulation and treatment response classification for major depression.Bioelectronic medicine · 2024Article
- Direct current stimulation as a non-invasive therapeutic alternative for treating autonomic or non-autonomic neurological disorders affecting breathing.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Effects of Catecholaminergic and Transcranial Direct Current Stimulation on Response Inhibition.The international journal of neuropsychopharmacology · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundDirect current stimulation (DCS) affects both neuronal firing rate and synaptic efficacy. The neuronal input/output (I/O) function determines the likelihood that a neuron elicits an action potential in response to synaptic input of a given strength. Changes of the neuronal I/O function by DCS may underlie previous observations in animal models and human testing, yet have not been directly assessed.
objectiveTest if the neuronal input/output function is affected by DCS
methodsUsing rat hippocampal brain slices and computational modeling, we provide evidence for how DCS modulates the neuronal I/O function.
resultsWe show for the first time that DCS modulates the likelihood of neuronal firing for a given and fixed synaptic input. Opposing polarization of soma and dendrite may have a synergistic effect for anodal stimulation, increasing the driving force of synaptic activity while simultaneously increasing spiking probability at the soma. For cathodal stimulation, however, the opposing effects tend to cancel. This results in an asymmetry in the strength of the effects of stimulation for opposite polarities.
conclusionsOur results may explain the asymmetries observed in acute and long term effects of transcranial direct current stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.