ArticleMalaria journal2016
Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02282293 (Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE Birth Cohort 2)
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses.The Journal of infectious diseases · 2020Pooled it
- Seasonal variation in the non-specific effects of BCG vaccination on neonatal mortality: three randomised controlled trials in Guinea-Bissau.BMJ global health · 2020Trial
- Regulatory T cell homing and activation is a signature of neonatal sepsis.Frontiers in immunology · 2024Article
- Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy.Nature communications · 2021Article
- The immune response to malaria in utero.Immunological reviews · 2020Review
- Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.Immunological reviews · 2020Review
- How does malaria in pregnancy impact malaria risk in infants?BMC medicine · 2018Article
- Modulation of innate immune responses at birth by prenatal malaria exposure and association with malaria risk during the first year of life.BMC medicine · 2018Article
- In utero priming of highly functional effector T cell responses to human malaria.Science translational medicine · 2018Article
- In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice.Environmental pollution (Barking, Essex : 1987) · 2018Article
- Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening malaria in peripheral and placental blood samples from pregnant women in Colombia.Malaria journal · 2018Article
- Placental implantation over prior cesarean scar causes activation of fetal regulatory T cells.Immunity, inflammation and disease · 2018Article
- High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection.Malaria journal · 2018Article
- Malaria incidence and prevalence during the first year of life in Nanoro, Burkina Faso: a birth-cohort study.Malaria journal · 2018Article
- Hyperparasitaemia during clinical malaria episodes in infants aged 0-24 months and its association with in utero exposure to Plasmodium falciparum.BMC research notes · 2018Article
- Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes.Malaria journal · 2017Article
- Management of malaria in pregnancy.The Indian journal of medical research · 2017Review
- Sex Disparity in Cord Blood FoxP3Open forum infectious diseases · 2017Article
- PERIPHERAL PARASITAEMIA AND ITS ASSOCIATION WITH PLASMA CYTOKINES LEVELS IN MALARIA-INFECTED PREGNANT WOMEN IN ABA, ABIA STATE, NIGERIA.African journal of infectious diseases · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIn malaria-endemic areas, the first exposure to malaria antigens often occurs in utero when the fetal immune system is poised towards the development of tolerance. Children exposed to placental malaria have an increased risk of clinical malaria in the first few years of life compared to unexposed children. Recent work has suggested the potential of pregnancy-associated malaria to induce immune tolerance in children living in malaria-endemic areas. A study was completed to evaluate the effect of malaria exposure during pregnancy on fetal immune tolerance and effector responses.
methodsUsing cord blood samples from a cohort of mother-infant pairs followed from early in pregnancy until delivery, flow cytometry analysis was completed to assess the relationship between pregnancy-associated malaria and fetal cord blood CD4 and dendritic cell phenotypes.
resultsCord blood FoxP3
conclusionTogether, these data indicate that in utero exposure to malaria drives expansion of both regulatory and effector T cells in the fetus, and that the timing of this exposure has a pivotal role in determining the polarization of the fetal immune response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.