Evidence map›Paper›PMID 27717208›Full record

ArticleAdvanced healthcare materials2016

Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo.

Spencer W Crowder, Daniel A Balikov, Timothy C Boire, Devin McCormack, Jung Bok Lee, Mukesh K Gupta, Melissa C Skala, Hak-Joon Sung

Open access · greenAbstract read
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Spencer W CrowderDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Daniel A BalikovDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Timothy C BoireDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Devin McCormackDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Jung Bok LeeDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Mukesh K GuptaDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Melissa C SkalaDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Hak-Joon SungDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Vanderbilt University · USImperial College London · GBYonsei University · KR

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
TRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1986 to 2011
$28.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6M
THREE-TIERED PREVENTION MODEL TO BETTER SERVE ALL STUDENP30HD015052 · NICHD · VANDERBILT UNIVERSITY · PI DYKENS, ELISABETH MAY · 1985 to 2014
$18.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneityR01CA205101 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2016 to 2020
$1.9M
Cellular-level Optical Metabolic Imaging to Predict Drug Response in CancerR01CA185747 · NCI · VANDERBILT UNIVERSITY · PI SKALA, MELISSA CAROLINE · 2014 to 2019
$1.6M
Thermosensitive injectable polymer-based stem cell therapy for limb ischemiaR21EB019509 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SUNG, HAK-JOON, YOUNG, PAMPEE P · 2015 to 2016
$433k
NCATS NIH HHS UL1 TR000445NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA185747NCI NIH HHS R01 CA205101NEI NIH HHS P30 EY008126NIBIB NIH HHS R21 EB019509NICHD NIH HHS P30 HD015052NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.

Indexed as

Biocompatible MaterialsCell AggregationCells, CulturedHumansMesenchymal Stem CellsPhenotypePolymersTissue ScaffoldsBiocompatible MaterialsPolymersangiogenesiscell-material interfaceinflammationmesenchymal stem cellsoutside-in signalingsynthetic copolymers

Identifiers

PMID27717208
PMCPMC5152909
OpenAlexW2526347042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.