Evidence map›Paper›PMID 27717188›Full record

ArticleJournal of veterinary internal medicine2016

Preliminary Investigation of Cardiovascular-Renal Disorders in Dogs with Chronic Mitral Valve Disease.

E Martinelli, C Locatelli, S Bassis, S Crosara, S Paltrinieri, P Scarpa, I Spalla, A M Zanaboni, C Quintavalla, P Brambilla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

E MartinelliDepartment of Veterinary Science and Public Health (DIVET), University of Milan, Milan, Italy. ms.martinelli.elisa@gmail.com.
C LocatelliDepartment of Veterinary Science and Public Health (DIVET), University of Milan, Milan, Italy.
S BassisComputer Science Department, University of Milan, Milan, Italy.
S CrosaraDepartment of Veterinary Sciences, University of Parma, Parma, Italy.
S PaltrinieriDepartment of Veterinary Science and Public Health (DIVET), University of Milan, Milan, Italy.
P ScarpaDepartment of Veterinary Science and Public Health (DIVET), University of Milan, Milan, Italy.
I SpallaRoyal Veterinary College, Department of Veterinary Clinical Sciences, United Kingdom.ORCID http://orcid.org/0000-0003-0039-1438
A M ZanaboniComputer Science Department, University of Milan, Milan, Italy.
C QuintavallaDepartment of Veterinary Sciences, University of Parma, Parma, Italy.
P BrambillaDepartment of Veterinary Science and Public Health (DIVET), University of Milan, Milan, Italy.
University of Milan · ITUniversity of Parma · ITRoyal Veterinary College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVeterinary literature lacks data about cardiovascular-renal disorders (CvRD) and cardiorenal-anemia syndrome (CRAS) in dogs. HYPOTHESIS: A direct correlation exists between ACVIM class and IRIS stage; chronic kidney disease (CKD) complicates chronic mitral valve disease (CMVD) more often than does anemia in dogs. ANIMALS: One hundred and fifty-eight client-owned dogs with CMVD.

methodsSignalment, physical examination findings, electrocardiography, thoracic radiographs, echocardiography, and blood analysis were retrospectively evaluated to assess the prevalence of CKD and anemia in dogs with CMVD and to investigate the relationships among ACVIM class, IRIS stage, and survival.

resultsThe prevalence of CKD and anemia in dogs with CMVD was significantly higher than in the general population of dogs. Dogs being treated for heart failure had a significantly higher prevalence of CKD than did dogs that had not received treatment. A statistically significant direct correlation was found between ACVIM class and IRIS stage. Severe heart disease, severe renal disease or both, furosemide administration, and advanced age at diagnosis of heart disease were associated with shorter survival time. Survival time of dogs affected by CvRD was statistically shorter than survival time of dogs affected by CMVD alone. CONCLUSION AND CLINICAL RELEVANCE: Chronic mitral valve disease is associated with increased prevalence of CKD and anemia in dogs. Treatment for medical management of heart failure may play a role in inducing CKD. Class of heart disease and IRIS stage were directly correlated. Cardiovascular-renal disorders decrease survival time compared to the only presence of CMVD alone, whereas anemia does not play a central role in worsening heart function.

Indexed as

AnemiaAnimalsCardio-Renal SyndromeChronic DiseaseDog DiseasesDogsFemaleHeart FailureKidney DiseasesMaleMitral Valve InsufficiencyAnemiaCardiorenal syndromeCardiovascular-renal disordersChronic kidney diseaseClinical pathologyEndocardiosisHeart diseaseHematology

Identifiers

PMID27717188
PMCPMC5032878
OpenAlexW2521203507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.