ArticlePLoS genetics2016
Local Transcriptional Control of YUCCA Regulates Auxin Promoted Root-Growth Inhibition in Response to Aluminium Stress in Arabidopsis.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.
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49 citing papers in PubMed, 125 citations in OpenAlex.
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- Auxin-Dependent Activation of RHD6-RSL4 Cascade Promotes Root Hair Growth Under Boron Deficiency in Arabidopsis Primary Root Apices.Plant, cell & environment · 2026Article
- Acidic and Alkaline pH Stresses Impair Tomato Seed Germination and Seedling Growth via Disruption of Reactive Oxygen Species and Auxin Homeostasis.Plants (Basel, Switzerland) · 2026Article
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- Decoding plant responses to waterlogging: from stress signals to molecular mechanisms and their future implications.Plant molecular biology · 2025Review
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- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- Aluminium stress tolerance byPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Role of transcriptional regulation in auxin-mediated response to abiotic stresses.Frontiers in genetics · 2024Review
- Recent advances in auxin biosynthesis and homeostasis.3 Biotech · 2023Review
- Al-induced CsUGT84J2 enhances flavonol and auxin accumulation to promote root growth in tea plants.Horticulture research · 2023Article
- Precise Regulation of the TAA1/TAR-YUCCA Auxin Biosynthesis Pathway in Plants.International journal of molecular sciences · 2023Review
- The Role of Light-Regulated Auxin Signaling in Root Development.International journal of molecular sciences · 2023Review
- Identification and evolution analysis ofFrontiers in plant science · 2023Article
- Aluminum stress signaling, response, and adaptive mechanisms in plants.Plant signaling & behavior · 2022Review
- Divergence in the ABA gene regulatory network underlies differential growth control.Nature plants · 2022Article
- Research Advances in the Mutual Mechanisms Regulating Response of Plant Roots to Phosphate Deficiency and Aluminum Toxicity.International journal of molecular sciences · 2022Review
- Aluminum in plant: Benefits, toxicity and tolerance mechanisms.Frontiers in plant science · 2022Review
- Different Functions ofFrontiers in plant science · 2022Article
- A Berberine Bridge Enzyme-Like Protein,Frontiers in plant science · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin is necessary for the inhibition of root growth induced by aluminium (Al) stress, however the molecular mechanism controlling this is largely unknown. Here, we report that YUCCA (YUC), which encodes flavin monooxygenase-like proteins, regulates local auxin biosynthesis in the root apex transition zone (TZ) in response to Al stress. Al stress up-regulates YUC3/5/7/8/9 in the root-apex TZ, which we show results in the accumulation of auxin in the root-apex TZ and root-growth inhibition during the Al stress response. These Al-dependent changes in the regulation of YUCs in the root-apex TZ and YUC-regulated root growth inhibition are dependent on ethylene signalling. Increasing or disruption of ethylene signalling caused either enhanced or reduced up-regulation, respectively, of YUCs in root-apex TZ in response to Al stress. In addition, ethylene enhanced root growth inhibition under Al stress was strongly alleviated in yuc mutants or by co-treatment with yucasin, an inhibitor of YUC activity, suggesting a downstream role of YUCs in this process. Moreover, ethylene-insensitive 3 (EIN3) is involved into the direct regulation of YUC9 transcription in this process. Furthermore, we demonstrated that PHYTOCHROME INTERACTING FACTOR4 (PIF4) functions as a transcriptional activator for YUC5/8/9. PIF4 promotes Al-inhibited primary root growth by regulating the local expression of YUCs and auxin signal in the root-apex TZ. The Al-induced expression of PIF4 in root TZ acts downstream of ethylene signalling. Taken together, our results highlight a regulatory cascade for YUCs-regulated local auxin biosynthesis in the root-apex TZ mediating root growth inhibition in response to Al stress.
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