ArticlePLoS neglected tropical diseases2016
Major Shift of Toxigenic V. cholerae O1 from Ogawa to Inaba Serotype Isolated from Clinical and Environmental Samples in Haiti.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Ancestral Origin and Dissemination Dynamics of Reemerging Toxigenic Vibrio cholerae, Haiti.Emerging infectious diseases · 2023Article
- A Cholera Case Imported from Bangladesh to Italy: Clinico-Epidemiological Management and Molecular Characterization in a Non-Endemic Country.Tropical medicine and infectious disease · 2023Article
- Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh.Nature communications · 2023Article
- Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti.Microbiology spectrum · 2023Article
- Serotype conversion geneFrontiers in microbiology · 2023Article
- Article
- Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae.Nature communications · 2020Article
- Genomic analysis of pathogenic isolates of Vibrio cholerae from eastern Democratic Republic of the Congo (2014-2017).PLoS neglected tropical diseases · 2020Article
- Characterisation ofThe Pan African medical journal · 2020Article
- A molecular and epidemiological study of Vibrio cholerae isolates from cholera outbreaks in southern Ghana.PloS one · 2020Article
- Descriptive epidemiology of cholera outbreak in Nigeria, January-November, 2018: implications for the global roadmap strategy.BMC public health · 2019Article
- Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice.PLoS neglected tropical diseases · 2019Article
- Epidemiological and molecular forensics of cholera recurrence in Haiti.Scientific reports · 2019Article
- Cyclic di-GMP Positively Regulates DNA Repair in Vibrio cholerae.Journal of bacteriology · 2018Article
- Controlling cholera in the Ouest Department of Haiti using oral vaccines.PLoS neglected tropical diseases · 2017Article
- Laboratory evaluation of immunochromatographic rapid diagnostic tests for cholera in Haiti.PloS one · 2017Article
- Cholera outbreak in 2022 among children in Karachi: Study of cases attending to a Tertiary Care Hospital.Pakistan journal of medical sciencesArticle
- Phage Types ofJournal of global infectious diseasesArticle
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7 authors at 1 institution in 1 country.
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Abstract
In October of 2010, an outbreak of cholera was confirmed in Haiti for the first time in more than a century. A single clone of toxigenic Vibrio cholerae O1 biotype El Tor serotype Ogawa strain was implicated as the cause. Five years after the onset of cholera, in October, 2015, we have discovered a major switch (ranging from 7 to 100%) from Ogawa serotype to Inaba serotype. Furthermore, using wbeT gene sequencing and comparative sequence analysis, we now demonstrate that, among 2013 and 2015 Inaba isolates, the wbeT gene, responsible for switching Ogawa to Inaba serotype, sustained a unique nucleotide mutation not found in isolates obtained from Haiti in 2012. Moreover, we show that, environmental Inaba isolates collected in 2015 have the identical mutations found in the 2015 clinical isolates. Our data indicate that toxigenic V. cholerae O1 serotype Ogawa can rapidly change its serotype to Inaba, and has the potential to cause disease in individuals who have acquired immunity against Ogawa serotype. Our findings highlight the importance of monitoring of toxigenic V. cholerae O1 and cholera in countries with established endemic disease.
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