Evidence map›Paper›PMID 27716690›Full record

Trial reportAnnals of cardiac anaesthesia

The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery.

Rabie Soliman, Gomaa Zohry

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of cardiac anaesthesia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06958913 (Comparison of Hemodynamic Response and Cardiac Protective Effects of Propofol Versus Dexmedetomidine at Induction of Anesthesia in Cardiac Surgery), which is not on this map. Cited by 18 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06958913 nacompletednot on this map

Comparison of Hemodynamic Response and Cardiac Protective Effects of Propofol Versus Dexmedetomidine at Induction of Anesthesia in Cardiac Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorPamukkale UniversityRan2022 to 2022Enrolled52ConditionsUse of Dexmedetomidine in Cardiac Surgery (CABG, Valve Replacement or Total Aortic Arch Replacement)ArmsPropofol group, Dexmedetomidine
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Article
  11. Hypertension in aortic coarctation.Frontiers in cardiovascular medicine · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Current Concepts in the Prevention of Perioperative Myocardial Injury.Translational perioperative and pain medicine · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rabie SolimanDepartment of Anesthesia, Cairo University, Cairo, Egypt.
Gomaa ZohryDepartment of Anesthesia, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to assess the effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery.

designA randomized prospective study.

settingCairo University, Egypt. MATERIALS AND

methodsThe study included 150 patients undergoing aortic vascular surgery.

interventionThe patients were classified into two groups (n = 75). Group D: The patients received a loading dose of 1 μg/kg dexmedetomidine over 15 min before induction and maintained as an infusion of 0.3 μg/kg/h to the end of the procedure. Group C: The patients received an equal volume of normal saline. The medication was prepared by the nursing staff and given to anesthetist blindly. MEASUREMENTS: The monitors included the heart rate, mean arterial blood pressure, central venous pressure, electrocardiogram (ECG), serum troponin I level, end-tidal sevoflurane, and total dose of morphine in addition transthoracic echocardiography to the postoperative in cases with elevated serum troponin I level. MAIN

resultsThe dexmedetomidine decreased heart rate and minimized the changes in blood pressure compared to control group (P < 0.05). Furthermore, it decreased the incidence of myocardial ischemia reflected by troponin I level, ECG changes, and the development of new regional wall motion abnormalities (P < 0.05). Dexmedetomidine decreased the requirement for nitroglycerin and norepinephrine compared to control group (P < 0.05). The incidence of hypotension and bradycardia was significantly higher with dexmedetomidine (P < 0.05).

conclusionThe dexmedetomidine is safe and effective in patients undergoing aortic vascular surgery. It decreases the changes in heart rate and blood pressure during the procedures. It provides cardiac protection in high-risk patients reflected by decreasing the incidence of myocardial ischemia and serum level of troponin. The main side effects of dexmedetomidine were hypotension and bradycardia.

Indexed as

Vascular Surgical ProceduresAortaBlood PressureDexmedetomidineDouble-Blind MethodEgyptElectrocardiographyFemaleHeartHeart RateHumansHypnotics and SedativesMaleMiddle AgedMyocardial IschemiaProspective StudiesDexmedetomidineHypnotics and SedativesTroponin I

Identifiers

PMID27716690
PMCPMC5070319

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.