Evidence map›Paper›PMID 27716670›Full record

ArticleJournal of Alzheimer's disease : JAD2017

BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function.

Krister Håkansson, Aurélie Ledreux, Kirk Daffner, Yvonne Terjestam, Patrick Bergman, Roger Carlsson, Miia Kivipelto, Bengt Winblad, Ann-Charlotte Granholm, Abdul Kadir H Mohammed

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05128396 (Successful Aging and Enrichment), which is not on this map. Cited by 106 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05128396 naactive not recruitingnot on this map

Successful Aging and Enrichment (SAGE): Effects of Environmental Stimulation on Cognitive Health and Neuroplasticity

TypeinterventionalSponsorBrigham and Women's HospitalRan2013 to 2026Enrolled72ConditionsCognitive Health, Healthy AgingArmsCognitive Stimulation, Mindfulness training, Physical Activity, Control Group
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Krister HåkanssonDepartment of Psychology, Linnaeus University, Växjö, Sweden.
Aurélie LedreuxDepartment of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC, USA.
Kirk DaffnerDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yvonne TerjestamDepartment of Psychology, Linnaeus University, Växjö, Sweden.
Patrick BergmanDepartment of Sport Science, Linnaeus University, Växjö, Sweden.
Roger CarlssonDepartment of Psychology, Linnaeus University, Växjö, Sweden.
Miia KivipeltoCenter for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.
Bengt WinbladCenter for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.
Ann-Charlotte GranholmDepartment of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC, USA.
Abdul Kadir H MohammedDepartment of Psychology, Linnaeus University, Växjö, Sweden.

Funding

High-Fat Diets and Memory Loss With AgingR01AG044920 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2012 to 2016
$1.4M
NIA NIH HHS R01 AG044920
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes in cortical thickness and synaptic density in response to physical activity and environmental enrichment. Previous studies suggest that physical exercise can augment BDNF levels, both in serum and the brain, but no other study has examined how different types of activities compare with physical exercise in their ability to affect BDNF levels. By using a balanced cross over experimental design, we exposed nineteen healthy older adults to 35-minute sessions of physical exercise, cognitive training, and mindfulness practice, and compared the resulting changes in mature BDNF levels between the three activities. We show that a single bout of physical exercise has significantly larger impact on serum BDNF levels than either cognitive training or mindfulness practice in the same persons. This is the first study on immediate BDNF effects of physical activity in older healthy humans and also the first study to demonstrate an association between serum BDNF responsivity to acute physical exercise and working memory function. We conclude that the BDNF increase we found after physical exercise more probably has a peripheral than a central origin, but that the association between post-intervention BDNF levels and cognitive function could have implications for BDNF responsivity in serum as a potential marker of cognitive health.

Indexed as

AgedAged, 80 and overAnalysis of VarianceBrainBrain-Derived Neurotrophic FactorCognitionCross-Over StudiesExerciseFemaleHealthy AgingHumansMaleMemory, Short-TermMindfulnessTeachingBrain-Derived Neurotrophic FactorAgingbrain-derived neurotrophic factorcognitive functioncognitive trainingcrossover designexercisegeriatricsintervention studymindfulnessneuroplasticity

Identifiers

PMID27716670
PMCPMC6135088

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.