ArticleReproductive biology and endocrinology : RB&E2016
Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation.
Article in Reproductive biology and endocrinology : RB&E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Surgical Techniques for a Parasitic Myoma Fed by the Mesentery: A Case Report and Technical Discussion.Cureus · 2026Article
- Induced and spontaneous uterine leiomyomas in animal models: a scoping review.Acta cirurgica brasileira · 2026Article
- A detailed transcriptome study uncovers the epigenetic characteristics associated with Aromatase inhibitor-induced masculinization in Takifugu rubripes larvae gonads.BMC genomics · 2025Article
- Iatrogenic Parasitic Leiomyoma in the Lower Right Abdomen: A Rare Case in Plastic Surgery.Cureus · 2024Article
- Acute abdomen by red degeneration of a parasitic leiomyoma: A case report and literature review.Radiology case reports · 2024Article
- Iatrogenic Parasitic Leiomyomas: A Late and Uncommon Complication After Laparoscopic Morcellation.Cureus · 2022Article
- Port-site implantation of parasitic leiomyoma after laparoscopic myomectomy and its histopathology.SAGE open medical case reports · 2020Article
- Iatrogenic parasitic myoma and iatrogenic adenomyoma after laparoscopic morcellation: A mini-review.Journal of advanced research · 2019Review
- Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report.Iranian journal of medical sciences · 2019Article
- Estrogen Effects on Wound Healing.International journal of molecular sciences · 2017Review
- Comment on "Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation".Reproductive biology and endocrinology : RB&E · 2017Article
- Response to comment on "Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation".Reproductive biology and endocrinology : RB&E · 2017Article
- Is Laparoscopic Power Morcellation of Fibroids a Cardinal Sin in 2017?Journal of obstetrics and gynaecology of India · 2017Article
- Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
- Two-phase laparoendoscopic single-site cervical ligament-sparing hysterectomy: An initial experience.Tzu chi medical journalArticle
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIatrogenic parasitic myomas (PMs), caused by intra-corporeal power morcellation during laparoscopy is gradually increasing. However, the pathogenesis and medical treatment of PMs remain largely unelucidated.
methodsLaparoscopically-induced PM xenografted mouse model was conducted by xenografting human uterine myoma fragments into the abdominal cavity of SCID mice and hormonal manipulation was performed using this mouse model to demonstrate the role of oestrogen in the development of implanted PMs. Immunohistochemistry of oestrogen receptor α (ERα), progesterone receptor (PR), vimentin, vascular endothelial growth factor (VEGF), microvessel density (MVD) and Ki-67 index was performed and compared.
resultsIn the patient with PMs, ERα, PR, angiogenesis and proliferative property expression were upregulated in PM lesions compared to uterine myomas. In the laparoscopically-induced PM mouse model, implanted myomas had more steroid receptor expressions, angiogenesis and proliferative property compared with pre-xenografted or non-implanted myoma. Depletion of oestrogen in the ovariectomized (OVX) mice decreased laparoscopically-induced PM implantations. In comparison, the implantations of PMs were increased with additional E2 supplement. Hormonal manipulation in the PM mouse model, including AI, GnRHa and SERM groups, were compared and AI significantly decreased the implantations, steroid receptor, angiogenesis, cell density, and proliferative index of PMs compared with control group. Furthermore, GnRHa significantly decreased VEGF and MVD expressions compared with control group.
conclusionsThese data highlight the crucial role of oestrogen in the development of laparoscopically-induced PMs and suggest that hormone manipulation may be a potential therapeutic agent.
trial registrationThis protocol was approved by the Human and Animal Institutional Review Board of Taipei Veterans General Hospital ( VGHIRB No 2014-10-002C on Nov. 17
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