Observational studyGenome medicine2016
Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks.
Observational study in Genome medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of transmission dynamic studies of methicillin-resistant Staphylococcus aureus in non-hospital residential facilities.BMC infectious diseases · 2018Pooled it
- Genomic Analysis of MRSA for Evaluating Local Transmission Dynamics in Geriatric Long-Term Care Facilities in Japan.Antibiotics (Basel, Switzerland) · 2025Article
- Identification of Long-Term Care Facility Residence From Admission Notes Using Large Language Models.JAMA network open · 2025Observational
- Article
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- A multi-center validation of the electronic health record admission source and discharge location fields against the clinical notes for identifying inpatients with long-term care facility exposure.Infection control and hospital epidemiology · 2024Article
- Infection control in long term care institutions for the elderly: A reflection document on the situation in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Review
- Colonization and transmission ofMicrobial genomics · 2023Article
- Framing Bacterial Genomics for Public Health (Care).Journal of clinical microbiology · 2021Article
- Molecular epidemiology of methicillin resistant Staphylococcus species in healthcare workers of a blood bank in the Brazilian Amazon.BMC microbiology · 2021Article
- Association between length of residence and prevalence of MRSA colonization among residents in geriatric long-term care facilities.BMC geriatrics · 2020Article
- Transmission and Long-Term Colonization Patterns ofInternational journal of environmental research and public health · 2020Article
- Dynamic Transmission ofInternational journal of environmental research and public health · 2020Review
- Status and potential of bacterial genomics for public health practice: a scoping review.Implementation science : IS · 2019Article
- Article
- Multi-step genomic dissection of a suspected intra-hospital Helicobacter cinaedi outbreak.Microbial genomics · 2018Article
- Infection control perception and behavior: a question of sex and gender? Results of the AHOI feasibility study.Infection and drug resistance · 2018Article
- The epidemiology and transmission of methicillin-resistant Staphylococcus aureus in the community in Singapore: study protocol for a longitudinal household study.BMC infectious diseases · 2017Article
- Genomic Characterization of USA300 Methicillin-Resistant Staphylococcus aureus (MRSA) to Evaluate Intraclass Transmission and Recurrence of Skin and Soft Tissue Infection (SSTI) Among High-Risk Military Trainees.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Challenges and Strategies for Prevention of Multidrug-Resistant Organism Transmission in Nursing Homes.Current infectious disease reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundLong-term care facilities (LTCF) are potential reservoirs for methicillin-resistant Staphylococcus aureus (MRSA), control of which may reduce MRSA transmission and infection elsewhere in the healthcare system. Whole-genome sequencing (WGS) has been used successfully to understand MRSA epidemiology and transmission in hospitals and has the potential to identify transmission between these and LTCF.
methodsTwo prospective observational studies of MRSA carriage were conducted in LTCF in England and Ireland. MRSA isolates were whole-genome sequenced and analyzed using established methods. Genomic data were available for MRSA isolated in the local healthcare systems (isolates submitted by hospitals and general practitioners).
resultsWe sequenced a total of 181 MRSA isolates from the two study sites. The majority of MRSA were multilocus sequence type (ST)22. WGS identified one likely transmission event between residents in the English LTCF and three putative transmission events in the Irish LTCF. WGS also identified closely related isolates present in colonized Irish residents and their immediate environment. Based on phylogenetic reconstruction, closely related MRSA clades were identified between the LTCF and their healthcare referral network, together with putative MRSA acquisition by LTCF residents during hospital admission.
conclusionsThese data confirm that MRSA is transmitted between residents of LTCF and is both acquired and transmitted to others in referral hospitals and beyond. Our data present compelling evidence for the importance of environmental contamination in MRSA transmission, reinforcing the importance of environmental cleaning. The use of WGS in this study highlights the need to consider infection control in hospitals and community healthcare facilities as a continuum.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.