Evidence map›Paper›PMID 27716400›Full record

ArticleMolecular brain2016

PERK regulates G

Siying Zhu, Barbara C McGrath, Yuting Bai, Xin Tang, Douglas R Cavener

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Translational Control in the Brain in Health and Disease.Cold Spring Harbor perspectives in biology · 2019
    Review
  9. Article
  10. Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  11. The role of CaDisease models & mechanisms · 2017
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Siying ZhuDepartment of Biology, Center of Cellular Dynamics, the Pennsylvania State University, University Park, PA, 16802, USA.
Barbara C McGrathDepartment of Biology, Center of Cellular Dynamics, the Pennsylvania State University, University Park, PA, 16802, USA.
Yuting BaiDepartment of Biology, Center of Cellular Dynamics, the Pennsylvania State University, University Park, PA, 16802, USA.
Xin TangWhitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA, 02142, USA.
Douglas R CavenerDepartment of Biology, Center of Cellular Dynamics, the Pennsylvania State University, University Park, PA, 16802, USA. drc9@psu.edu.
Pennsylvania State University · USWhitehead Institute for Biomedical Research · US

Funding

Physiological Regulation of Proinsulin Quality and Quantity Control in the PancreR01DK088140 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI CAVENER, DOUGLAS R. · 2010 to 2018
$2.6M
NIDDK NIH HHS R01 DK088140
6 · The paper itself

Abstract

PERK (EIF2AK3) is an ER-resident eIF2α kinase required for behavioral flexibility and metabotropic glutamate receptor-dependent long-term depression via its translational control. Motivated by the recent discoveries that PERK regulates Ca

Indexed as

AnimalsCalciumCells, CulturedCerebral CortexeIF-2 KinaseEndoplasmic ReticulumGTP-Binding Protein alpha Subunits, Gq-G11Mice, Inbred C57BLMice, KnockoutModels, BiologicalNeuronsCalciumeIF-2 KinaseGTP-Binding Protein alpha Subunits, Gq-G11Ca2+Gq protein-coupled receptorPERKReceptor-operated Ca2+ entry

Identifiers

PMID27716400
PMCPMC5045583
OpenAlexW2525186835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.